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00925njm 22002777a 4500 dc Guirado, Pedro author Paytubi, Sonia author Miró, Elisenda author Iglesias-Torrens, Yaidelis author Navarro, Ferran author Cerdà-Cuéllar, Marta author Attolini, Camille Stephan-Otto author Balsalobre, Carlos author Madrid, Cristina author 2020-02-26 Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtB gene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells. Guirado, Pedro, Sonia Paytubi, Elisenda Miró, Yaidelis Iglesias-Torrens, Ferran Navarro, Marta Cerdà-Cuéllar, Camille Stephan-Otto Attolini, Carlos Balsalobre, and Cristina Madrid. 2020. "Differential Distribution Of The Wlan And Cgtb Genes, Associated With Guillain-Barré Syndrome, In Campylobacter Jejuni Isolates From Humans, Broiler Chickens, And Wild Birds". Microorganisms 8 (3): 325. MDPI AG. doi:10.3390/microorganisms8030325. 2076-2607 http://hdl.handle.net/20.500.12327/703 https://doi.org/10.3390/microorganisms8030325 Differential distribution of the wlaN and cgtB genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds