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oai:recercat.cat:20.500.12327/7032025-10-22T11:13:23Zcom_2072_4428com_2072_4427col_2072_487898

2025-10-22T11:13:23Z urn:hdl:20.500.12327/703 Differential distribution of the wlaN and cgtB genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds Guirado, Pedro Paytubi, Sonia Miró, Elisenda Iglesias-Torrens, Yaidelis Navarro, Ferran Cerdà-Cuéllar, Marta Attolini, Camille Stephan-Otto Balsalobre, Carlos Madrid, Cristina Producció Animal Sanitat Animal Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtB gene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells. 2025-10-22T11:13:23Z 2025-10-22T11:13:23Z 2020-02-26 info:eu-repo/semantics/article Guirado, Pedro, Sonia Paytubi, Elisenda Miró, Yaidelis Iglesias-Torrens, Ferran Navarro, Marta Cerdà-Cuéllar, Camille Stephan-Otto Attolini, Carlos Balsalobre, and Cristina Madrid. 2020. "Differential Distribution Of The Wlan And Cgtb Genes, Associated With Guillain-Barré Syndrome, In Campylobacter Jejuni Isolates From Humans, Broiler Chickens, And Wild Birds". Microorganisms 8 (3): 325. MDPI AG. doi:10.3390/microorganisms8030325. 2076-2607 http://hdl.handle.net/20.500.12327/703 https://doi.org/10.3390/microorganisms8030325 eng Microorganisms MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2013-45339R/ES/Identificación de factores implicados en la transmisión de la campilobacteriosis por alimentos/ http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Attribution 4.0 International MDPI