2026-04-17T12:08:14Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/5632025-10-22T11:12:15Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Mármol-Sánchez, Emilio
author
Quintanilla, Raquel
author
Cardoso, Taina F.
author
Jordana Vidal, Jordi
author
Amills, Marcel
other
Producció Animal
group
Genètica i Millora Animal
2025-10-22T11:12:15Z
2025-10-22T11:12:15Z
2019-06-21
Mármol-Sánchez, Emilio, Raquel Quintanilla, Taina F. Cardoso, Jordi Jordana Vidal, and Marcel Amills. 2019. "Polymorphisms Of The Cryptochrome 2 And Mitoguardin 2 Genes Are Associated With The Variation Of Lipid-Related Traits In Duroc Pigs". Scientific Reports 9 (1). Springer Science and Business Media LLC. doi:10.1038/s41598-019-45108-z.
2045-2322
http://hdl.handle.net/20.500.12327/563
https://doi.org/10.1038/s41598-019-45108-z
The genetic factors determining the phenotypic variation of porcine fatness phenotypes are still largely
unknown. We investigated whether the polymorphism of eight genes (MIGA2, CRY2, NPAS2, CIART,
ARNTL2, PER1, PER2 and PCK1), which display diferential expression in the skeletal muscle of fasted
and fed sows, is associated with the variation of lipid and mRNA expression phenotypes in Duroc
pigs. The performance of an association analysis with the GEMMA software demonstrated that the
rs330779504 SNP in the MIGA2 gene is associated with LDL concentration at 190 days (LDL2, corrected
P-value=0.057). Moreover, the rs320439526 SNP of the CRY2 gene displayed a signifcant association
with stearic acid content in the longissimus dorsi muscle (LD C18:0, corrected P-value=0.015). Both
SNPs were also associated with the mRNA levels of the corresponding genes in the gluteus medius
skeletal muscle. From a biological perspective these results are meaningful because MIGA2 protein
plays an essential role in mitochondrial fusion, a process tightly connected with the energy status of
the cell, while CRY2 is a fundamental component of the circadian clock. However, inclusion of these two
SNPs in chromosome-wide association analyses demonstrated that they are not located at the peaks of
signifcance for the two traits under study (LDL2 for rs330779504 and LD C18:0 for rs320439526), thus
implying that these two SNPs do not have causal efects.
eng
Attribution 4.0 International
Polymorphisms of the cryptochrome 2 and mitoguardin 2 genes are associated with the variation of lipid-related traits in Duroc pigs
info:eu-repo/semantics/article