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oai:recercat.cat:20.500.12327/47102025-10-22T11:05:43Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Campos, Carolina author Ibañez-Lligoña, Marta author Colomer‑Castell, Sergi author Gregori, Josep author Garcia‑Cehic, Damir author Andrés, Cristina author Piñana, Maria author González‑Sánchez, Alejandra author Rando‑Segura, Ariadna author Esperalba, Juliana author Saubí, Narcis author Cortese, Maria Francesca author Tabernero, David author Rodriguez-Frias, Francisco author Ferrer, Roser author Esteban, Juan Ignacio author Kakze-van der Honing, Renate W. author Kampfraath, Andries A. author Vergara-Alert, Júlia author Segalés, Joaquim author van der Poel, Wim H. M. author Pumarola, Tomàs author Antón, Andrés author Quer, Josep author 2025-06-30 SARS‐CoV‐2 has evolved from early variants dominating the first (B.1.5, B.1.1) and second (B.1.177) pandemic waves, which exhibited a higher frequency of minority mutants with deletions leading to Defective Viral Genomes (DVGs) in the spike region near the S1/S2 cleavage site than the Alpha, Beta, and Delta variants. The emergence of Omicron has significantly altered the dominant variant profile, with Omicron subvariants now representing 100% of circulating viruses. To monitor the evolution and adaptation of Omicron in the human population, a deep‐sequencing study was performed in RNA samples of BA.1, BA.1.1, BA.2, BA.5, BQ.1.1, XBB.1.5 and BA.2.86 Omicron subvariants. The findings reveal two occurrences of similar evolutionary patterns within SARS‐CoV‐2 characterized by a shift from a significant to a very low production of DVGs. This event suggests that DVGs might play a role in the virus's spread and adaptation for persistence in infected humans. Campos, Carolina, Marta Ibañez‐Lligoña, Sergi Colomer‑Castell, Josep Gregori, Damir Garcia‑Cehic, Cristina Andrés, Maria Piñana, Júlia Vergara, et al. 2025. “Deep Sequencing Reveals Dual Evolution of SARS‐CoV‐2: Insights Into Defective Genomes From Wuhan‐Hu‐1 Variants to Omicron Subvariants.” Journal of Medical Virology 97 (7). https://doi.org/10.1002/jmv.70476. 0146-6615 http://hdl.handle.net/20.500.12327/4710 https://doi.org/10.1002/jmv.70476 Deep Sequencing Reveals Dual Evolution of SARS-CoV-2: Insights Into Defective Genomes From Wuhan-Hu-1 Variants to Omicron Subvariants