2026-04-17T04:18:31Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/3842025-10-22T11:13:40Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Javaheri, B.
author
Razi, H.
author
Piles, M.
author
de Souza, R.
author
Chang, Y.-M.
author
Maric-Mur, I.
author
Hopkinson, M.
author
Lee, P.D.
author
Pitsillides, A. A.
other
Producció Animal
group
Genètica i Millora Animal
2025-10-22T11:13:40Z
2025-10-22T11:13:40Z
2018-03-19
Javaheri, B., H. Razi, M. Piles, R. de Souza, Y.-M. Chang, I. Maric-Mur, M. Hopkinson, P.D. Lee, and A.A. Pitsillides. 2018. "Sexually Dimorphic Tibia Shape Is Linked To Natural Osteoarthritis In STR/Ort Mice". Osteoarthritis And Cartilage 26 (6): 807-817. Elsevier BV. doi:10.1016/j.joca.2018.03.008.
1063-4584
http://hdl.handle.net/20.500.12327/384
https://doi.org/10.1016/j.joca.2018.03.008
Objectives:Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OAspontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. Weexploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explorewhether early divergence in tibial bone mass or shape are linked to emergent OA.Method:We undertook detailed micro-CT comparisons of trabecular and cortical bone, multiple struc-tural/architectural parameters andfinite element modelling (FEM) of the tibia from male and female STR/Ort and CBA mice at 8e10 (pre-OA), 18e20 (OA onset) and 40þweeks (advanced OA) of age.Results:We found higher trabecular bone mass in female STR/Ort than in either OA-prone male STR/Ortor non-prone CBA mice. Cortical bone, as expected, showed greater cross-sectional area in male thanfemale CBA, which surprisingly was reversed in STR/Ort mice. STR/Ort also exhibited higher cortical bonemass than CBA mice. Our analyses revealed similar tibial ellipticity, yet greater predicted resistance totorsion in male than female CBA mice. In contrast, male STR/Ort exhibited greater ellipticity than bothfemale STR/Ort and CBA mice at specific cortical sites. Longitudinal analysis revealed greater tibia cur-vature and shape deviations in male STR/Ort mice that coincided with onset and were more pronouncedin late OA.Conclusion:Generalised higher bone mass in STR/Ort mice is more marked in non OA-prone females, butpre-OA divergence in bone shape is restricted to male STR/Ort mice in which OA develops spontaneously.
eng
Attribution 4.0 International
Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice
info:eu-repo/semantics/article