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Influence of Enrofloxacin Administration and α-Tocopheryl Acetate Supplemented Diets on Oxidative Stability of Broiler Tissues Carreras, I. Castellari, Massimo Garcia-Regueiro, Jose A Guerrero, Luis Esteve-Garcia, Enric Sárraga, C. Producció Animal Indústries Alimentàries Nutrició Animal Funcionalitat i Seguretat Alimentària Qualitat i Tecnologia Alimentària 636 663/664 The objective of this study was to assess the oxidative stability and presence of antibiotic residues in tissues of broilers fed diets supplemented with α-tocopheryl acetate and treated with enrofloxacin. The activities of antioxidant enzymes and antibiotic concentrations in chicken breast, leg, and liver were determined. Ironinduced TBA-reactive substances (TBARS) and vitamin E were evaluated in muscles. The antioxidant effectiveness of vitamin E was reflected by TBARS values being lower in antioxidant-supplemented treatments than in the other dietary groups. On the other hand, antioxidant enzyme activities were not substantially affected by dietary treatments. The concentration of enrofloxacin in tissues was considerable, even after withdrawal 12 d before slaughter. Con trary to the findings in previous studies, enrofloxacin was not extensively metabolized to ciprofloxacin. Supplementation of the diet with 100 mg/kg of α-tocopheryl acetate did not have a significant effect on the level of antibiotic found in breast muscle samples. When comparing treatments without antibiotic withdrawal time, α-tocopheryl acetate supplementation led to a significant decrease in enrofloxacin level in leg and liver samples. These results showed that mutual interactions between different molecules could modify the drug residues in the tissue, which should be taken into account when considering the drug administration and the establishment of a correct withdrawal time This work was supported by INIA (MAPA, MCyT, Spain) project SC00-005. I. Carreras received an FI grant from CIRIT (Generalitat de Catalunya). The authors thank Narcı ´s Sais for his technical assistance and Lluı ´s Llaurado ´ for his helpful contribution in rearing the chickens for the experiment info:eu-repo/semantics/publishedVersion 2004-05-01 info:eu-repo/semantics/article Carreras, I., M. Castellari, J.A. García Regueiro, L. Guerrero, E. Esteve-Garcia, and C. Sárraga. 2004. “Influence of Enrofloxacin Administration and Α-tocopheryl Acetate Supplemented Diets on Oxidative Stability of Broiler Tissues.” Poultry Science 83 (5): 796-802. doi: 10.1093/ps/83.5.796 0032-5791 http://hdl.handle.net/20.500.12327/3685 https://doi.org/10.1093/ps/83.5.796 eng Poultry Science INIA/ /SC00-005/ES/ / Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess 7 Oxford University Press