2026-04-17T22:50:18Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/36762025-10-22T11:30:55Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Erill, Ivan
author
Campoy, Susana
author
Mazon, Gerard
author
Barbé, Jordi
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:30:55Z
2025-10-22T11:30:55Z
2006-01-01
Erill, Ivan, Susana Campoy, Gerard Mazon, and Jordi Barbé. 2006. “Dispersal and Regulation of an Adaptive Mutagenesis Cassette in the Bacteria Domain.” Nucleic Acids Research 34 (1): 66–77. doi: 10.1093/nar/gkj412
0305-1048
http://hdl.handle.net/20.500.12327/3676
https://doi.org/10.1093/nar/gkj412
Recently, a multiple gene cassette with mutagenic
translation synthesis activity was identified and
shown to be under LexA regulation in several proteobacteria species. In this work, we have traced
down instances of this multiple gene cassette across
the bacteria domain. Phylogenetic analyses show
that this cassette has undergone several reorganizations since its inception in the actinobacteria, and
that it has dispersed across the bacterial domain
through a combination of vertical inheritance, lateral
gene transfer and duplication. In addition, our analyses show that LexA regulation of this multiple
gene cassette is persistent in all the phyla in which
it has been detected, and suggest that this regulation
is prompted by the combined activity of two of its
constituent genes: a polymerase V homolog and
an alpha subunit of the DNA polymerase III
eng
Attribution 4.0 International
Dispersal and regulation of an adaptive mutagenesis cassette in the bacteria domain
info:eu-repo/semantics/article