2026-04-18T04:18:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12327/36172025-10-22T11:01:07Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Tarres, Joaquim author JOVÉ JUNCÀ, TEODOR author Hernández‑Banqué, Carles author González-Rodríguez, Olga author Ganges, Llilianne author Gol, Sofia author Díaz, Marta author Reixach, Josep author Pena, Ramona N. author Quintanilla, Raquel author Ballester Devis, Maria author 2024-12-18 Breeding animals to produce more robust and disease-resistant pig populations becomes a complementary strategy to the more conventional methods of biosecurity and vaccination. The objective of this study was to explore the ability of a panel of genetic markers and immunity parameters to predict the survival rates during a natural PRRSV outbreak. Ten-week-old female Duroc pigs (n = 129), obtained from 61 sows and 20 boars, were naturally infected with a highly pathogenic PRRSV genotype 1 strain. Prior to infection, piglets were screened for immunity parameters (IgG levels in plasma and SOX13 mRNA expression in blood) and genetic markers previously associated to PRRSV immune response and immunity traits. Additionally, the 20 boars were genotyped with a panel of 132 single nucleotide polymorphisms (SNPs). Survival analysis showed that mortality was significantly higher for animals with low basal IgG levels in plasma and/or high SOX13 mRNA expression in blood. The genotypes of sires for SNPs associated with IgG plasma levels, CRP in serum, percentage of γδ T cells, lymphocyte phagocytic capacity, total number of lymphocytes and leukocytes, and MCV and MCH were significantly associated with the number of surviving offspring. Furthermore, CD163 and GBP5 markers were also associated to piglet survival. The effects of these SNPs were polygenic and cumulative, survival decreased from 94 to 21% as more susceptible alleles were accumulated for the different markers. Our results confirmed the existence of genetic variability in survival after PRRSV infection and provided a set of genetic markers and immunity traits associated with PRRS resistance. Tarrés, Joaquim, Teodor Jové-Juncà, Carles Hernández-Banqué, Olga González-Rodríguez, Llilianne Ganges, Sofia Gol, Marta Díaz, et al. 2024. “Insights Into Genetic Determinants of Piglet Survival During a PRRSV Outbreak.” Veterinary Research 55 (1): 160. https://doi.org/10.1186/s13567-024-01421-8. 0928-4249 http://hdl.handle.net/20.500.12327/3617 https://doi.org/10.1186/s13567-024-01421-8 Insights into genetic determinants of piglet survival during a PRRSV outbreak