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oai:recercat.cat:20.500.12327/33122025-10-22T11:07:49Zcom_2072_4428com_2072_4427col_2072_487898

2025-10-22T11:07:49Z urn:hdl:20.500.12327/3312 Impact of adding eicosapentaenoic and docosahexaenoic acid-rich fish oil in sow and piglet diets on blood oxylipins and immune indicators of weaned piglets Llauradó-Calero, Eudald Badiola, Ignacio Samarra, I. Lizardo, Rosil Torrallardona, David Esteve-Garcia, Enric Tous, Núria Producció Animal Nutrició Animal Sanitat Animal Weaning is a decisive event in piglets’ life. This study aimed to evaluate whether the inclusion of fish oil, rich in eicosapentaenoic and docosahexaenoic acids (EPA and DHA), in sow and piglet diets, increased the concentration of anti-inflammatory molecules in the blood of weaned piglets and whether the effect was dependent on the pigs being born with either low or a high birth BW (bBW). Thirty-six sows in four consecutive batches were randomly distributed between a control diet with animal fat (15 g/kg in gestation and 30 g/kg in lactation) or a n-3 long-chain fatty acid diet (LCFA; totally or half replacing animal fat by fish oil during gestation and lactation, respectively) from service until weaning (ca. 28 days). At birth, the two lightest (LBW) and the two heaviest (HBW) piglets in each litter were identified and, at weaning, grouped in pens by pairs prioritising their bBW. Pens were further distributed into a control (30 g/kg animal fat) or n-3 LCFA diet (totally replacing animal fat by fish oil) for 28 days. At the end of the trial, blood was collected from piglets in the first batch (n = 48). Serum fatty acids (FAs) were quantified by GC, plasma oxylipins by ultra-HPLC-MS, and plasma immune indicators by ELISA. An interaction between piglet diet and bBW for average daily gain (P = 0.020) and average daily feed intake (P = 0.014) during the whole postweaning indicated that dietary n-3 LCFA promoted LBW piglets to have a similar growth and intake than HBW piglets reaching 1.5 kg average BW more at the end of the postweaning period than LBW control piglets. Fish oil in piglet diets also increased the concentrations of total n-3 FA, EPA and DHA (all P < 0.001), their resultant oxylipins, particularly their hydroxy derivatives from lipoxygenase enzymatic pathway (all P < 0.001) and tended to increase immunoglobulin M (P = 0.067) in blood. Regarding the bBW category, LBW piglets tend to increase tumour necrosis factor a in plasma (P = 0.083) compared to HBW. It is concluded that fish oil in postweaning diets could enhance the daily gain and feed intake of LBW piglets, increasing the concentration of serum n-3 FAs and their derived oxylipins in plasma. 2025-10-22T11:07:49Z 2025-10-22T11:07:49Z 2024-08-23 info:eu-repo/semantics/article Llauradó-Calero, Eudald, Ignacio Badiola, Iris Samarra, Rosil Lizardo, David Torrallardona, Enric Esteve-Garcia, and Núria Tous. 2024. “Impact of Adding Eicosapentaenoic and Docosahexaenoic Acids-rich Fish Oil in Sow and Piglet Diets on Blood Oxylipins and Immune Indicators of Weaned Piglets.” Animal, 18 (10): 101317. doi: 10.1016/j.animal.2024.101317 1751-7311 http://hdl.handle.net/20.500.12327/3312 https://doi.org/10.1016/j.animal.2024.101317 eng Animal INIA/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2017-00086-C02-01/ES/Suplementación pre y postnatal de ácidos grasos n-3 de cadena larga. Impacto sobre la supervivencia, el estado inmunitario y marcadores epigenéticos de los lechones en razas comerciales/ http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier