2026-04-14T05:00:04Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/32712025-10-22T11:23:30Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Casellas, J.
author
Varona Aguado, Luis
author
Muñoz, G.
author
Ramírez, O.
author
Barragán, C.
author
Tomás, A.
author
Martínez-Giner, M.
author
Ovilo, C.
author
Sánchez, A.
author
Noguera, José Luis
author
Rodríguez, C.
other
Producció Animal
group
Genètica i Millora Animal
2025-10-22T11:23:30Z
2025-10-22T11:23:30Z
2008-02-01
Casellas, J., L. Varona, G. Muñoz, O. Ramírez, C. Barragán, A. Tomás, M. Martínez-Giner, et al. 2008. “Empirical Bayes Factor Analyses of Quantitative Trait Loci for Gestation Length in Iberian × Meishan F2 Sows.” Animal 2 (2): 177–183. doi: 10.1017/s1751731107001085
1751-7311
http://hdl.handle.net/20.500.12327/3271
https://doi.org/10.1017/S1751731107001085
The aim of this study was to investigate chromosomal regions affecting gestation length in sows. An experimental F2 cross
between Iberian and Meishan pig breeds was used for this purpose and we genotyped 119 markers covering the 18 porcine
autosomal chromosomes. Within this context, we have developed a new empirical Bayes factor (BF) approach to compare
between nested models, with and without the quantitative trait loci (QTL) effect, and after including the location of the QTL
as an unknown parameter in the model. This empirical BF can be easily calculated from the output of a Markov chain
Monte Carlo sampling by averaging conditional densities at the null QTL effects. Linkage analyses were performed in each
chromosome using an animal model to account for infinitesimal genetic effects. Initially, three QTL were detected at
chromosomes 6, 8 and 11 although, after correcting for multiple testing, only the additive QTL located in cM 110 of
chromosome 8 remained. For this QTL, the allelic effect of substitution of the Iberian allele increased gestation length in
0.521 days, with a highest posterior density region at 95% ranged between 0.121 and 0.972 days. Although future studies
are necessary to confirm if detected QTL is relevant and segregating in commercial pig populations, a hot-spot on the genetic
regulation of gestation length in pigs seems to be located in chromosome 8.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Empirical Bayes factor analyses of quantitative trait loci for gestation length in Iberian x Meishan F2 sows
info:eu-repo/semantics/article