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oai:recercat.cat:20.500.12327/32712025-10-22T11:23:30Zcom_2072_4428com_2072_4427col_2072_487898

2025-10-22T11:23:30Z urn:hdl:20.500.12327/3271 Empirical Bayes factor analyses of quantitative trait loci for gestation length in Iberian x Meishan F2 sows Casellas, J. Varona Aguado, Luis Muñoz, G. Ramírez, O. Barragán, C. Tomás, A. Martínez-Giner, M. Ovilo, C. Sánchez, A. Noguera, José Luis Rodríguez, C. Producció Animal Genètica i Millora Animal The aim of this study was to investigate chromosomal regions affecting gestation length in sows. An experimental F2 cross between Iberian and Meishan pig breeds was used for this purpose and we genotyped 119 markers covering the 18 porcine autosomal chromosomes. Within this context, we have developed a new empirical Bayes factor (BF) approach to compare between nested models, with and without the quantitative trait loci (QTL) effect, and after including the location of the QTL as an unknown parameter in the model. This empirical BF can be easily calculated from the output of a Markov chain Monte Carlo sampling by averaging conditional densities at the null QTL effects. Linkage analyses were performed in each chromosome using an animal model to account for infinitesimal genetic effects. Initially, three QTL were detected at chromosomes 6, 8 and 11 although, after correcting for multiple testing, only the additive QTL located in cM 110 of chromosome 8 remained. For this QTL, the allelic effect of substitution of the Iberian allele increased gestation length in 0.521 days, with a highest posterior density region at 95% ranged between 0.121 and 0.972 days. Although future studies are necessary to confirm if detected QTL is relevant and segregating in commercial pig populations, a hot-spot on the genetic regulation of gestation length in pigs seems to be located in chromosome 8. 2025-10-22T11:23:30Z 2025-10-22T11:23:30Z 2008-02-01 info:eu-repo/semantics/article Casellas, J., L. Varona, G. Muñoz, O. Ramírez, C. Barragán, A. Tomás, M. Martínez-Giner, et al. 2008. “Empirical Bayes Factor Analyses of Quantitative Trait Loci for Gestation Length in Iberian × Meishan F2 Sows.” Animal 2 (2): 177–183. doi: 10.1017/s1751731107001085 1751-7311 http://hdl.handle.net/20.500.12327/3271 https://doi.org/10.1017/S1751731107001085 eng Animal MICYT/ /AGL2000-1229-C03/ES/Detección de QTLS y genes candidatos que afectan a caracteres reproductivos de interés económico en el porcino/ MEC/ /AGL2004-08368-C03/ES/Mapeo e identificación de genes que afectan a caracteres reproductivos y de supervivencia en porcino en un cruce F2 (Meishan X Ibérico), mediante técnicas de expresión diferencial y genes candidatos/GAN http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International Cambridge University Press