2026-04-13T00:07:50Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/31942025-10-22T11:04:32Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Rodríguez, Javier M.
author
Moreno, Leticia Tais
author
Alejo, Alí
author
Lacasta, Anna
author
Rodriguez, Fernando
author
Salas, María L.
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:04:32Z
2025-10-22T11:04:32Z
2015-11-30
Rodríguez, Javier M., Leticia Tais Moreno, Alí Alejo, Anna Lacasta, Fernando Rodríguez, and María L. Salas. 2015. "Genome Sequence Of African Swine Fever Virus BA71, The Virulent Parental Strain Of The Nonpathogenic And Tissue-Culture Adapted BA71V". PLOS ONE 10 (11): e0142889. doi:10.1371/journal.pone.0142889.
1932-6203
http://hdl.handle.net/20.500.12327/3194
https://doi.org/10.1371/journal.pone.0142889
The strain BA71V has played a key role in African swine fever virus (ASFV) research. It was the first genome sequenced, and remains the only genome completely determined. A large part of the studies on the function of ASFV genes, viral transcription, replication, DNA repair and morphogenesis, has been performed using this model. This avirulent strain was obtained by adaptation to grow in Vero cells of the highly virulent BA71 strain. We report here the analysis of the genome sequence of BA71 in comparison with that of BA71V. They possess the smallest genomes for a virulent or an attenuated ASFV, and are essentially identical except for a relatively small number of changes. We discuss the possible contribution of these changes to virulence. Analysis of the BA71 sequence allowed us to identify new similarities among ASFV proteins, and with database proteins including two ASFV proteins that could function as a two-component signaling network.
eng
Attribution 4.0 International
Genome Sequence of African Swine Fever Virus BA71, the Virulent Parental Strain of the Nonpathogenic and Tissue-Culture Adapted BA71V
info:eu-repo/semantics/article