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oai:recercat.cat:20.500.12327/31282025-10-22T11:27:17Zcom_2072_4428com_2072_4427col_2072_487898

Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues Duran-Montge, P. Theil, P. K. Lauridsen, C. Esteve-Garcia, Enric Producció Animal Nutrició Animal Little is known about pig gene expressions related to dietary fatty acids (FAs) and most work have been conducted in rodents. The aim of this study was to investigate how dietary fats regulate fat metabolism of pigs in different tissues. Fifty-six crossbred gilts (62 6 5.2 kg BW) were fed one of seven dietary treatments (eight animals per treatment): a semi-synthetic diet containing a very low level of fat (no fat (NF)) and six fat-supplemented diets (ca. 10%) based on barley and soybean meal. The supplemental fat sources were tallow (T), high-oleic sunflower oil (HOSF), sunflower oil (SFO), linseed oil (LO), blend (FB) (55% T, 35% SFO and 10% LO) and fish oil (FO) blend (40% FO and 60% LO). Pigs were slaughtered at 100 kg BW and autopsies from liver, adipose tissue and muscle semimembranousus were collected for qPCR. The messenger ribonucleic acid (mRNA) abundances of genes related to lipogenesis were modified due to dietary treatments in both liver (sterol regulatory elementbinding protein-1 (SREBP-1), acetyl CoA carboxylase (ACACA) and stearoyl CoA desaturase (SCD)) and adipose tissue (fatty acid synthase (FASN), ACACA and SCD), but were not affected in semimembranousus muscle. In the liver, the mRNA abundances of genes encoding lipogenic enzymes were highest in pigs fed HOSF and lowest in pigs fed FO. In adipose tissue, the mRNA abundances were highest in pigs fed the NF diet and lowest in pigs fed T. The study demonstrated that dietary FAs stimulate lipogenic enzyme gene expression differently in liver, fat and muscles tissues. 2025-10-22T11:27:17Z 2025-10-22T11:27:17Z 2025-10-22T11:27:17Z 2009-01-01 info:eu-repo/semantics/article Duran-Montgé, P., P. K. Theil, C. Lauridsen, and E. Esteve-Garcia. 2009. “Dietary Fat Source Affects Metabolism of Fatty Acids in Pigs as Evaluated by Altered Expression of Lipogenic Genes in Liver and Adipose Tissues.” Animal 3 (4): 535–542. doi: 10.1017/s1751731108003686 1751-7311 http://hdl.handle.net/20.500.12327/3128 https://doi.org/10.1017/S1751731108003686 eng Animal MEC/Programa nacional de recursos y tecnologías agroalimentarias/RTA03-060-C2-1/ES/Efecto del perfil en ácidos grasos de ración sobre el depósito y distribución de lípidos en el cerdo/ http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier