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00925njm 22002777a 4500 dc Bertran, Kateri author Pérez-Ramírez, Elisa author Busquets, Núria author Dolz, Roser author Ramis, Antonio author Darji, Ayub author Abad, Francesc Xavier author Valle, Rosa author Chaves, Aida author Serra Gironella, Joan author Barral, Marta author Höfle, Ursula author Majó, Natàlia author 2011-02-07 An experimental infection with highly pathogenic avian influenza virus (HPAIV) and low pathogenic avian influenza virus (LPAIV) was carried out in red-legged partridges (Alectoris rufa) in order to study clinical signs, gross and microscopic lesions, and viral distribution in tissues and viral shedding. Birds were infected with a HPAIV subtype H7N1 (A/Chicken/Italy/5093/1999) and a LPAIV subtype H7N9 (A/Anas crecca/Spain/1460/2008). Uninoculated birds were included as contacts in both groups. In HPAIV infected birds, the first clinical signs were observed at 3 dpi, and mortality started at 4 dpi, reaching 100% at 8 dpi. The presence of viral antigen in tissues and viral shedding were confirmed by immunohistochemistry and quantitative real time RT-PCR (qRRT-PCR), respectively, in all birds infected with HPAIV. However, neither clinical signs nor histopathological findings were observed in LPAIV infected partridges. In addition, only short-term viral shedding together with seroconversion was detected in some LPAIV inoculated animals. The present study demonstrates that the red-legged partridge is highly susceptible to the H7N1 HPAIV strain, causing severe disease, mortality and abundant viral shedding and thus contributing to the spread of a potential local outbreak of this virus. In contrast, our results concerning H7N9 LPAIV suggest that the red-legged partridge is not a reservoir species for this virus. Bertran, Kateri, Elisa Pérez-Ramírez, Núria Busquets, Roser Dolz, Antonio Ramis, Ayub Darji, Francesc Xavier Abad, et al. 2011. “Pathogenesis and Transmissibility of Highly (H7N1) and Low (H7N9) Pathogenic Avian Influenza Virus Infection in Red-legged Partridge (Alectoris Rufa).” Veterinary Research 42 (1): 24. doi: 10.1186/1297-9716-42-24 0928-4249 http://hdl.handle.net/20.500.12327/2999 https://doi.org/10.1186/1297-9716-42-24 Pathogenesis and transmissibility of highly (H7N1) and low (H7N9) pathogenic avian influenza virus infection in red-legged partridge (Alectoris rufa)