2026-04-14T06:50:39Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/29622025-10-22T11:00:07Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Mussá, Tufária
author
Rodríguez-Cariño, Carolina
author
Sánchez-Chardi, Alejandro
author
Baratelli, Massimiliano
author
Costa-Hurtado, Mar
author
Fraile, Lorenzo
author
Domínguez, Javier
author
Aragon, Virginia
author
Montoya, Maria
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:00:07Z
2025-10-22T11:00:07Z
2012-11-16
Mussá, Tufária, Carolina Rodríguez-Cariño, Alejandro Sánchez-Chardi, Massimiliano Baratelli, Mar Costa-Hurtado, Lorenzo Fraile et al. 2012. “Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells”. Veterinary Research 43: 80. doi:10.1186/1297-9716-43-80
0928-4249
http://hdl.handle.net/20.500.12327/2962
https://doi.org/10.1186/1297-9716-43-80
Pigs possess a microbiota in the upper respiratory tract that includes Haemophilus parasuis. Pigs are also considered
the reservoir of influenza viruses and infection with this virus commonly results in increased impact of bacterial
infections, including those by H. parasuis. However, the mechanisms involved in host innate responses towards
H. parasuis and their implications in a co-infection with influenza virus are unknown. Therefore, the ability of a
non-virulent H. parasuis serovar 3 (SW114) and a virulent serovar 5 (Nagasaki) strains to interact with porcine bone
marrow dendritic cells (poBMDC) and their modulation in a co-infection with swine influenza virus (SwIV) H3N2 was
examined. At 1 hour post infection (hpi), SW114 interaction with poBMDC was higher than that of Nagasaki, while
at 8 hpi both strains showed similar levels of interaction. The co-infection with H3N2 SwIV and either SW114 or
Nagasaki induced higher levels of IL-1β, TNF-α, IL-6, IL-12 and IL-10 compared to mock or H3N2 SwIV infection
alone. Moreover, IL-12 and IFN-α secretion differentially increased in cells co-infected with H3N2 SwIV and Nagasaki.
These results pave the way for understanding the differences in the interaction of non-virulent and virulent strains
of H. parasuis with the swine immune system and their modulation in a viral co-infection.
eng
Attribution 4.0 International
Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells
info:eu-repo/semantics/article