2026-04-14T07:54:15Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/29622025-10-22T11:00:07Zcom_2072_4428com_2072_4427col_2072_487898
2025-10-22T11:00:07Z
urn:hdl:20.500.12327/2962
Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells
Mussá, Tufária
Rodríguez-Cariño, Carolina
Sánchez-Chardi, Alejandro
Baratelli, Massimiliano
Costa-Hurtado, Mar
Fraile, Lorenzo
Domínguez, Javier
Aragon, Virginia
Montoya, Maria
Producció Animal
Sanitat Animal
Pigs possess a microbiota in the upper respiratory tract that includes Haemophilus parasuis. Pigs are also considered
the reservoir of influenza viruses and infection with this virus commonly results in increased impact of bacterial
infections, including those by H. parasuis. However, the mechanisms involved in host innate responses towards
H. parasuis and their implications in a co-infection with influenza virus are unknown. Therefore, the ability of a
non-virulent H. parasuis serovar 3 (SW114) and a virulent serovar 5 (Nagasaki) strains to interact with porcine bone
marrow dendritic cells (poBMDC) and their modulation in a co-infection with swine influenza virus (SwIV) H3N2 was
examined. At 1 hour post infection (hpi), SW114 interaction with poBMDC was higher than that of Nagasaki, while
at 8 hpi both strains showed similar levels of interaction. The co-infection with H3N2 SwIV and either SW114 or
Nagasaki induced higher levels of IL-1β, TNF-α, IL-6, IL-12 and IL-10 compared to mock or H3N2 SwIV infection
alone. Moreover, IL-12 and IFN-α secretion differentially increased in cells co-infected with H3N2 SwIV and Nagasaki.
These results pave the way for understanding the differences in the interaction of non-virulent and virulent strains
of H. parasuis with the swine immune system and their modulation in a viral co-infection.
2025-10-22T11:00:07Z
2025-10-22T11:00:07Z
2012-11-16
info:eu-repo/semantics/article
Mussá, Tufária, Carolina Rodríguez-Cariño, Alejandro Sánchez-Chardi, Massimiliano Baratelli, Mar Costa-Hurtado, Lorenzo Fraile et al. 2012. “Differential interactions of virulent and non-virulent H. parasuis strains with naïve or swine influenza virus pre-infected dendritic cells”. Veterinary Research 43: 80. doi:10.1186/1297-9716-43-80
0928-4249
http://hdl.handle.net/20.500.12327/2962
https://doi.org/10.1186/1297-9716-43-80
eng
Veterinary Research
MEC/ /CSD2006-00007/ES/Patogenia de infecciones víricas del cerdo/PORCIVIR
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2009-12945-C02-01/ES/Vacunas Basadas En Capsidas Vacias (Vlps) Quimericas Frente Al Virus De La Gripe Porcina: Estudios Inmunologicos/
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-22200-C02-01/ES/Caracterización de la respuesta inmune inducida por cepas del virus de la gripe porcina circulante en España. Desarrollo de vacunas basadas en VLPs quiméricas/
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-15232/ES/Selección de candidatos vacunales para bloquear los pasos iniciales de la infección por Haemophilus parasuis/
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
Attribution 4.0 International
BMC