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oai:recercat.cat:20.500.12327/29002025-10-22T11:34:17Zcom_2072_4428com_2072_4427col_2072_487898

Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species Costa, Taiana Chaves, Aida J Valle, Rosa Darji, Ayub van Riel, Debby Kuiken, Thijs Majó, Natàlia Ramis, Antonio Producció Animal Sanitat Animal This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant, ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6 receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general, in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various avian species might reflect a potentially decisive factor in the emergence of new viral strains. 2025-10-22T11:34:17Z 2025-10-22T11:34:17Z 2025-10-22T11:34:17Z 2012-04-10 info:eu-repo/semantics/article Costa, Teresa, Andrea Chaves, Rosa Valle, Ayub Darji, Debby Van Riel, Thijs Kuiken, Natàlia Majó, and Antonio Ramis. 2012. “Distribution Patterns of Influenza Virus Receptors and Viral Attachment Patterns in the Respiratory and Intestinal Tracts of Seven Avian Species.” Veterinary Research 43 (1): 28. doi:10.1186/1297-9716-43-28. 0928-4249 http://hdl.handle.net/20.500.12327/2900 https://doi.org/10.1186/1297-9716-43-28 eng Veterinary Research EC/FP6/44098/EU/Molecular factors and mechanisms of transmission and pathogenicity of highly pathogenic Avian Influenza Virus/EUROFLU MICINN/Programa Nacional de Proyectos de Investigación Fundamental/RTA2011-00111-C03-01/ES/Dinámica viral en diferentes especies aviares: mecanismos moleculares de transmisión y patogenicidad/ http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Attribution 4.0 International BMC