2026-04-17T01:51:17Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/28862025-10-22T11:12:28Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Rodon, Jordi
author
Sachse, Martin
author
Te, Nigeer
author
Segalés, Joaquim
author
Bensaid, Albert
author
Risco, Cristina
author
Serra Gironella, Joan
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:12:28Z
2025-10-22T11:12:28Z
2024-03
Rodón, Jordi, Martin Sachse, Nigeer Te, Joaquím Segalés, Albert Bensaid, Cristina Risco, and Júlia Vergara‐Alert. 2023. “Middle East Respiratory Coronavirus (MERS-CoV) Internalized by Llama Alveolar Macrophages Does Not Result in Virus Replication or Induction of Pro-inflammatory Cytokines.” Microbes and Infection, 26 (3): 105252. doi:10.1016/j.micinf.2023.105252.
1286-4579
http://hdl.handle.net/20.500.12327/2886
https://doi.org/10.1016/j.micinf.2023.105252
Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells
in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high proinflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic
carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of
camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses.
MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles.
Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon
MERS-CoV sensing.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
info:eu-repo/semantics/article