2026-04-17T20:01:56Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/27212025-10-22T11:33:29Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Gaide, Nicolas
author
Filaire, Fabien
author
Bertran, Kateri
author
Crispo, Manuela
author
Dirat, Malorie
author
Secula, Aurélie
author
Foret-Lucas, Charlotte
author
Payré, Bruno
author
Perlas, Albert
author
Cantero, Guillermo
author
Majó, Natàlia
author
Soubies, Sébastien
author
Guérin, Jean-Luc
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:33:29Z
2025-10-22T11:33:29Z
2023-11-03
Gaide, Nicolas, Fabien Filaire, Kateri Bertran, Manuela Crispo, Malorie Dirat, Aurélie Sécula, Charlotte Foret‐Lucas, et al. 2023. “The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks”. Emerging microbes & infections 12 (2): 2272644. doi: 10.1080/22221751.2023.2272644.
2222-1751
http://hdl.handle.net/20.500.12327/2721
https://doi.org/10.1080/22221751.2023.2272644
Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry.
However, it is unclear whether feathers play an active role in viral transmission. This study aims to investigate the
contribution of the feather epithelium to the dissemination of clade 2.3.4.4b goose/Guangdong/1996 lineage H5
HPAIVs in the environment, based on natural and experimental infections of domestic mule and Muscovy ducks.
During the 2016–2022 outbreaks, H5 HPAIVs exhibited persistent and marked feather epitheliotropism in naturally
infected commercial ducks. Infection of the feather epithelium resulted in epithelial necrosis and disruption, as well
as the production and environmental shedding of infectious virions. Viral and feather antigens colocalized in dust
samples obtained from poultry barns housing naturally infected birds. In summary, the feather epithelium
contributes to viral replication, and it is a likely source of environmental infectious material. This underestimated
excretion route could greatly impact the ecology of HPAIVs, facilitating airborne and preening-related infections
within a flock, and promoting prolonged viral infectivity and long-distance viral transmission between poultry farms.
eng
Attribution-NonCommercial 4.0 International
The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks
info:eu-repo/semantics/article