2026-04-14T06:43:02Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/27212025-10-22T11:33:29Zcom_2072_4428com_2072_4427col_2072_487898
2025-10-22T11:33:29Z
urn:hdl:20.500.12327/2721
The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks
Gaide, Nicolas
Filaire, Fabien
Bertran, Kateri
Crispo, Manuela
Dirat, Malorie
Secula, Aurélie
Foret-Lucas, Charlotte
Payré, Bruno
Perlas, Albert
Cantero, Guillermo
Majó, Natàlia
Soubies, Sébastien
Guérin, Jean-Luc
Producció Animal
Sanitat Animal
Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry.
However, it is unclear whether feathers play an active role in viral transmission. This study aims to investigate the
contribution of the feather epithelium to the dissemination of clade 2.3.4.4b goose/Guangdong/1996 lineage H5
HPAIVs in the environment, based on natural and experimental infections of domestic mule and Muscovy ducks.
During the 2016–2022 outbreaks, H5 HPAIVs exhibited persistent and marked feather epitheliotropism in naturally
infected commercial ducks. Infection of the feather epithelium resulted in epithelial necrosis and disruption, as well
as the production and environmental shedding of infectious virions. Viral and feather antigens colocalized in dust
samples obtained from poultry barns housing naturally infected birds. In summary, the feather epithelium
contributes to viral replication, and it is a likely source of environmental infectious material. This underestimated
excretion route could greatly impact the ecology of HPAIVs, facilitating airborne and preening-related infections
within a flock, and promoting prolonged viral infectivity and long-distance viral transmission between poultry farms.
2025-10-22T11:33:29Z
2025-10-22T11:33:29Z
2023-11-03
info:eu-repo/semantics/article
Gaide, Nicolas, Fabien Filaire, Kateri Bertran, Manuela Crispo, Malorie Dirat, Aurélie Sécula, Charlotte Foret‐Lucas, et al. 2023. “The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks”. Emerging microbes & infections 12 (2): 2272644. doi: 10.1080/22221751.2023.2272644.
2222-1751
http://hdl.handle.net/20.500.12327/2721
https://doi.org/10.1080/22221751.2023.2272644
eng
Emerging Microbes & Infections
EC/H2020/731014/EU/Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation/VetBioNet
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
Attribution-NonCommercial 4.0 International
Taylor and Francis