2026-04-18T05:59:59Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12327/27052025-10-22T11:21:24Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Muñoz-Fontela, César author Widerspick, Lina author Albrecht, Randy A. author Beer, Martin author Carroll, Miles W. author de Wit, Emmie author Diamond, Diamond author Dowling, William E. author Funnell, Simon G. P. author García-Sastre, Adolfo author Gerhards, Nora M. author de Jong, Rineke author Munster, Vincent J. author Neyts, Johan author Perlman, Stanley author Reed, Douglas S. author Richt, Juergen A. author Riveros-Balta, Ximena author Roy, Chad J. author Salguero, Francisco J. author Schotsaert, Michael author Schwartz, Lauren M. author Seder, Robert A. author Segalés, Joaquim author Vasan, Seshadri S. author Henao-Restrepo, Ana María author Barouch, Dan H. author 2022-01-13 AU The:global Pleaseco response nfirmthata tollhe Coronavirus adinglevelsa Disease rerepres 2019 entedcor (COVID-19) rectly: is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age. Muñoz-Fontela, César, Lina Widerspick, Randy A. Albrecht, Martin Beer, Miles W. Carroll, Emmie De Wit, Michael S. Diamond, et al. 2022.“Advances and Gaps in SARS-CoV-2 Infection Models.” PLOS Pathogens 18(1): e1010161. doi:10.1371/journal.ppat.1010161. 1553-7366 http://hdl.handle.net/20.500.12327/2705 https://doi.org/10.1371/journal.ppat.1010161 Advances and gaps in SARS-CoV-2 infection models