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oai:recercat.cat:20.500.12327/20782025-10-22T11:12:09Zcom_2072_4428com_2072_4427col_2072_487898

Efficacy Studies against PCV-2 of a New Trivalent Vaccine including PCV-2a and PCV-2b Genotypes and Mycoplasma hyopneumoniae When Administered at 3 Weeks of Age Pleguezuelos, Patricia Sibila, Marina Ramírez, Carla López-Jiménez, Rosa Pérez, Diego Huerta, Eva Llorens, Anna Maria Pérez, Mónica Correa-Fiz, Florencia Mancera Gracia, José Carlos Taylor, Lucas P. Smith, Jennifer Bandrick, Meggan Borowski, Stasia Saunders, Gillian Segalés, Joaquim Lopez-Soria, Sergio Fort, Maria Balasch, Mónica Producció Animal Sanitat Animal This study aimed to evaluate the efficacy of a new trivalent vaccine containing inactivated Porcine Circovirus 1-2a and 1-2b chimeras and a Mycoplasma hyopneumoniae bacterin administered to pigs around 3 weeks of age. This trivalent vaccine has already been proved as efficacious in a splitdose regimen but has not been tested in a single-dose scenario. For this purpose, a total of four studies including two pre-clinical and two clinical studies were performed. Globally, a significant reduction in PCV-2 viraemia and faecal excretion was detected in vaccinated pigs compared to non-vaccinated animals, as well as lower histopathological lymphoid lesion plus PCV-2 immunohistochemistry scorings, and incidence of PCV-2-subclinical infection. Moreover, in field trial B, a significant increase in body weight and in average daily weight gain were detected in vaccinated animals compared to the non-vaccinated ones. Circulation of PCV-2b in field trial A and PCV-2a plus PCV-2d in field trial B was confirmed by virus sequencing. Hence, the efficacy of this new trivalent vaccine against a natural PCV-2a, PCV-2b or PCV-2d challenge was demonstrated in terms of reduction of histopathological lymphoid lesions and PCV-2 detection in tissues, serum and faeces, as well as improvement of production parameters. 2025-10-22T11:12:09Z 2025-10-22T11:12:09Z 2025-10-22T11:12:09Z 2022-12-09 info:eu-repo/semantics/article Pleguezuelos, Patricia, Marina Sibila, Carla Ramírez, Rosa López-Jiménez, Diego Pérez, Eva Huerta, Anna Maria Llorens, Mónica Pérez, Florencia Correa-Fiz, José Carlos Mancera Gracia, Lucas P. Taylor, Jennifer Smith, Meggan Bandrick, Stasia Borowski, Gillian Saunders, Joaquim Segalés, Sergio López-Soria, Maria Fort and Mónica Balasch. 2022. "Efficacy Studies Against PCV-2 Of A New Trivalent Vaccine Including PCV-2A And PCV-2B Genotypes And Mycoplasma Hyopneumoniae When Administered At 3 Weeks Of Age". Vaccines 10 (12): 2108. doi:10.3390/vaccines10122108. 2076-393X http://hdl.handle.net/20.500.12327/2078 https://doi.org/10.3390/vaccines10122108 eng Vaccines http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Attribution 4.0 International MDPI