2026-04-18T04:30:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12327/20272025-10-22T11:19:12Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Terriente Palacios, Carlos author Rubiño Campoy, Susana author Hortós, Maria author Peteiro, César author Castellari, Massimo author 2022-12-02 Prevention and control of diseases and delaying the signs of ageing are nowadays one of the major goals of biomedicine. Sirtuins, a family of NAD+ dependent deacylase enzymes, could be pivotal targets of novel preventive and therapeutic strategies to achieve such aims. SIRT1 activating and inhibiting compounds, such as polyphenols and bioactive peptides, have been proposed to be involved in the development of many human diseases. The objective of this work was to assess and compare the antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates (EPHs) from a wide number of algae species (24 commercial samples and 12 samples harvested off the Atlantic coast of northern Spain). High antioxidant activities were observed in EPHs from red and green seaweed species. Moreover, 19 samples exhibited SIRT1 activation, while EPHs from the 16 samples were SIRT1 inhibitors. Pearson’s correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and (2) concentrations of taurine, homotaurine, and amino acid gamma aminobutyric acid in EPHs and their SIRT1 modulation activity. Terriente-Palacios, Carlos, Susana Rubiño, Maria Hortós, César Peteiro, and Massimo Castellari. 2022. "Taurine, Homotaurine, GABA And Hydrophobic Amino Acids Content Influences “In Vitro” Antioxidant And SIRT1 Modulation Activities Of Enzymatic Protein Hydrolysates From Algae". Scientific Reports 12 (1). doi:10.1038/s41598-022-25130-4. 2045-2322 http://hdl.handle.net/20.500.12327/2027 https://doi.org/10.1038/s41598-022-25130-4 Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae