2026-04-13T02:13:14Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/19872025-10-22T11:19:36Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Bosch Camós, Laia
author
Alonso, Uxía
author
Esteve-Codina, Anna
author
Chang, Chia-Yu
author
Martín-Mur, Beatriz
author
Accensi, Francesc
author
Muñoz, Marta
author
Navas, María J.
author
Dabad, Marc
author
Vidal, Enric
author
Pina-Pedrero, Sonia
author
Pleguezuelos, Patricia
author
Caratù, Ginevra
author
Salas, María L.
author
Liu, Lihong
author
Bataklieva, Stanimira
author
Gavrilov, Boris
author
Rodriguez, Fernando
author
Argilaguet, Jordi
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:19:36Z
2025-10-22T11:19:36Z
2022-11-09
Bosch-Camós, Laia, Uxía Alonso, Anna Esteve-Codina, Chia-Yu Chang, Beatriz Martín-Mur, Francesc Accensi, and Marta Muñoz et al. 2022. "Cross-Protection Against African Swine Fever Virus Upon Intranasal Vaccination Is Associated With An Adaptive-Innate Immune Crosstalk". PLOS Pathogens 18 (11): e1010931. doi:10.1371/journal.ppat.1010931.
1553-7366
http://hdl.handle.net/20.500.12327/1987
https://doi.org/10.1371/journal.ppat.1010931
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease in wild boars and domestic pigs. Lack of effective vaccines hampers the control of virus spread, thus increasing the pressure on the scientific community for urgent solutions. However, knowledge on the immune components associated with protection is very limited. Here we characterized the in vitro recall response induced by immune cells from pigs intranasally vaccinated with the BA71ΔCD2 deletion mutant virus. Vaccination conferred dose-dependent cross-protection associated with both ASFV-specific antibodies and IFNγ-secreting cells. Importantly, bulk and single-cell transcriptomics of blood and lymph node cells from vaccinated pigs revealed a positive feedback from adaptive to innate immunity. Indeed, activation of Th1 and cytotoxic T cells was concomitant with a rapid IFNγ-dependent triggering of an inflammatory response characterized by TNF-producing macrophages, as well as CXCL10-expressing lymphocytes and cross-presenting dendritic cells. Altogether, this study provides a detailed phenotypic characterization of the immune cell subsets involved in cross-protection against ASFV, and highlights key functional immune mechanisms to be considered for the development of an effective ASF vaccine.
eng
Attribution 4.0 International
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
info:eu-repo/semantics/article