2026-04-18T07:39:22Zhttps://recercat.cat/oai/request
oai:recercat.cat:20.500.12327/19852025-10-22T11:17:42Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT author Ainsua-Enrich, Erola author Pedreño-Lopez, Núria author Bracke, Carmen author Ávila-Nieto, Carlos author Rodríguez de la Concepción, María Luisa author Pradenas, Edwards author Trinité, Benjamin author Marfil, Silvia author Miranda, Cristina author González, Sandra author Toledo, Ruth author Font, Marta author Benet, Susana author Escribà, Tuixent author Jimenez-Moyano, Esther author Peña, Ruth author Cedeño, Samandhy author Prado, Julia G. author Mothe, Beatriz author Brander, Christian author Izquierdo-Useros, Nuria author Serra Gironella, Joan author Segalés, Joaquim author Massanella, Marta author Benitez, Rosa María author Romero, Alba author Molina-Morant, Daniel author Blanco, Julià author Clotet, Bonaventura author Mateu, Lourdes author Pedro-Botet, María Luisa author Carrillo, Jorge other Producció Animal group Sanitat Animal 2025-10-22T11:17:42Z 2025-10-22T11:17:42Z 2022-10-28 Ainsua-Enrich, Erola, Núria Pedreño-Lopez, Carmen Bracke, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Edwards Pradenas, and Benjamin Trinité et al. 2022. "Kinetics Of Immune Responses Elicited After Three Mrna COVID-19 Vaccine Doses In Predominantly Antibody-Deficient Individuals". Iscience 25 (11): 105455. doi:10.1016/j.isci.2022.105455. 2589-0042 http://hdl.handle.net/20.500.12327/1985 https://doi.org/10.1016/j.isci.2022.105455 Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: unclassified primary antibody-deficiency (unPAD, n = 9), common variable immunodeficiency (CVID, n = 12), combined immunodeficiency (CID, n = 1), and thymoma with immunodeficiency (TID, n = 1). unPAD patients and healthy controls (HCs, n = 10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Of interest, these PAD groups showed lower levels of Spike-specific IFN-γ-producing cells. CVID individuals also presented diminished CD8+T cells. CID and TID patients developed cellular but not humoral responses. Although the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies. eng Attribution 4.0 International Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals info:eu-repo/semantics/article