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oai:recercat.cat:20.500.12327/19712025-10-22T11:17:20Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT author Fernández-Bastit, Leira author Marfil, Silvia author Pradenas, Edwards author Valle, Rosa author Roca, Núria author Rodon Aldrufeu, Jordi author Pailler García, Lola author Trinité, Benjamin author Parera, Mariona author Noguera-Julian, Marc author Martorell, Jaume author Izquierdo-Useros, Nuria author Carrillo, Jorge author Clotet, Bonaventura author Blanco, Julià author Vergara-Alert, Júlia author Segalés, Joaquim other Producció Animal group Sanitat Animal 2025-10-22T11:17:20Z 2025-10-22T11:17:20Z 2022-09-27 Fernández-Bastit, Leira, Silvia Marfil, Edwards Pradenas, Rosa Valle, Núria Roca, Jordi Rodon, and Lola Pailler-García et al. (2022). "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and humoral responses against different variants of concern in domestic pet animals and stray cats from North-Eastern Spain". Transboundary and Emerging Diseases, 00, 1– 12. doi:10.1111/tbed.14714 1865-1674 http://hdl.handle.net/20.500.12327/1971 https://doi.org/10.1111/tbed.14714 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic in humans, is able to infect several domestic, captive and wildlife animal species. Since reverse zoonotic transmission to pets has been demonstrated, it is crucial to determine their role in the epidemiology of the disease to prevent further spillover events and major spread of SARS-CoV-2. In the present study, we determined the presence of virus and the seroprevalence to SARS-CoV-2, as well as the levels of neutralizing antibodies (nAbs) against several variants of concern (VOCs) in pets (cats, dogs and ferrets) and stray cats from North-Eastern of Spain. We confirmed that cats and dogs can be infected by different VOCs of SARS-CoV-2 and, together with ferrets, are able to develop nAbs against the ancestral (B.1), Alpha (B.1.1.7), Beta (B.1.315), Delta (B.1.617.2) and Omicron (BA.1) variants, with lower titres against the latest in dogs and cats, but not in ferrets. Although the prevalence of active SARS-CoV-2 infection measured as direct viral RNA detection was low (0.3%), presence of nAbs in pets living in COVID-19-positive households was relatively high (close to 25% in cats, 10% in dogs and 40% in ferrets). It is essential to continue monitoring SARS-CoV-2 infections in these animals due to their frequent contact with human populations, and we cannot discard the probability of a higher animal susceptibility to new potential SARS-CoV-2 VOCs. eng Attribution-NonCommercial 4.0 International Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and humoral responses against different variants of concern in domestic pet animals and stray cats from North-Eastern Spain info:eu-repo/semantics/article