2026-04-18T04:09:31Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/18392025-10-22T11:28:06Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Bach, Alex
author
Aris, Anna
author
Guasch, Isabel
other
Producció Animal
group
Producció de Remugants
2025-10-22T11:28:06Z
2025-10-22T11:28:06Z
2017-12-11
Bach, Alex, Anna Aris, and Isabel Guasch. 2017. "Consequences Of Supplying Methyl Donors During Pregnancy On The Methylome Of The Offspring From Lactating And Non-Lactating Dairy Cattle". PLOS ONE 12 (12): e0189581. doi:10.1371/journal.pone.0189581.
1932-6203
http://hdl.handle.net/20.500.12327/1839
https://doi.org/10.1371/journal.pone.0189581
The aim of this study was to evaluate the potential effects of methyl donor supplementation of pregnant animals in the presence or absence of a concomitant lactation on the methylome of the offspring. Twenty Holstein cows, 10 nulliparous (non-lactating while pregnant) and 10 multiparous (lactating while pregnant) were blocked by parity and randomly assigned to an i.m. weekly injections of a placebo (CTRL) or a solution containing methyl donors (MET). After calving, 5 calves randomly selected from each treatment (two born to non-lactating and three to lactating dams) were blood-sampled to determine their full methylome. There were more than 2,000 CpG differentially methylated between calves born to CTRL
and those born to MET, and also between calves born to lactating and non-lactating dams. Most of the differences affected genes involved in immune function, cell growth regulation and differentiation, kinase activity, and ion channeling. We conclude that the coexistence of pregnancy and lactation affects the methylome of the offspring, and that supplementation of methyl donors early in gestation has also consequences on the methylome.
eng
Attribution 4.0 International
Consequences of supplying methyl donors during pregnancy on the methylome of the offspring from lactating and non-lactating dairy cattle
info:eu-repo/semantics/article