2026-04-14T06:52:43Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/17382025-10-22T11:27:44Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Ballester, Maria
author
Ramayo-Caldas, Yuliaxis
author
Revilla, Manuel
author
Corominas, Jordi
author
Castelló, Anna
author
Estellé, Jordi
author
Fernández, Ana I.
author
Folch, Josep M.
other
Producció Animal
group
Genètica i Millora Animal
2025-10-22T11:27:44Z
2025-10-22T11:27:44Z
2017-04-19
Ballester, Maria, Yuliaxis Ramayo-Caldas, Manuel Revilla, Jordi Corominas, Anna Castelló, Jordi Estellé, Ana I. Fernández, and Josep M. Folch. 2017. "Integration Of Liver Gene Co-Expression Networks And Egwas Analyses Highlighted Candidate Regulators Implicated In Lipid Metabolism In Pigs". Scientific Reports 7 (1). doi:10.1038/srep46539.
2045-2322
http://hdl.handle.net/20.500.12327/1738
https://doi.org/10.1038/srep46539
In the present study, liver co-expression networks and expression Genome Wide Association Study
(eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional
regulatory mechanisms of meat quality traits in pigs. With this purpose, the liver mRNA expression of
44 candidates genes related with lipid metabolism was analysed in 111 Iberian x Landrace backcross
animals. The eGWAS identified 92 eSNPs located in seven chromosomal regions and associated with
eight genes: CROT, CYP2U1, DGAT1, EGF, FABP1, FABP5, PLA2G12A, and PPARA. Remarkably,
cis-eSNPs associated with FABP1 gene expression which may be determining the C18:2(n-6)/
C18:3(n-3) ratio in backfat through the multiple interaction of DNA variants and genes were identified.
Furthermore, a hotspot on SSC8 associated with the gene expression of eight genes was identified
and the TBCK gene was pointed out as candidate gene regulating it. Our results also suggested that
the PI3K-Akt-mTOR pathway plays an important role in the control of the analysed genes highlighting
nuclear receptors as the NR3C1 or PPARA. Finally, sex-dimorphism associated with hepatic lipid
metabolism was identified with over-representation of female-biased genes. These results increase our
knowledge of the genetic architecture underlying fat composition traits.
eng
Attribution 4.0 International
Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs
info:eu-repo/semantics/article