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00925njm 22002777a 4500 dc Ballester, Maria author Ramayo-Caldas, Yuliaxis author Revilla, Manuel author Corominas, Jordi author Castelló, Anna author Estellé, Jordi author Fernández, Ana I. author Folch, Josep M. author 2017-04-19 In the present study, liver co-expression networks and expression Genome Wide Association Study (eGWAS) were performed to identify DNA variants and molecular pathways implicated in the functional regulatory mechanisms of meat quality traits in pigs. With this purpose, the liver mRNA expression of 44 candidates genes related with lipid metabolism was analysed in 111 Iberian x Landrace backcross animals. The eGWAS identified 92 eSNPs located in seven chromosomal regions and associated with eight genes: CROT, CYP2U1, DGAT1, EGF, FABP1, FABP5, PLA2G12A, and PPARA. Remarkably, cis-eSNPs associated with FABP1 gene expression which may be determining the C18:2(n-6)/ C18:3(n-3) ratio in backfat through the multiple interaction of DNA variants and genes were identified. Furthermore, a hotspot on SSC8 associated with the gene expression of eight genes was identified and the TBCK gene was pointed out as candidate gene regulating it. Our results also suggested that the PI3K-Akt-mTOR pathway plays an important role in the control of the analysed genes highlighting nuclear receptors as the NR3C1 or PPARA. Finally, sex-dimorphism associated with hepatic lipid metabolism was identified with over-representation of female-biased genes. These results increase our knowledge of the genetic architecture underlying fat composition traits. Ballester, Maria, Yuliaxis Ramayo-Caldas, Manuel Revilla, Jordi Corominas, Anna Castelló, Jordi Estellé, Ana I. Fernández, and Josep M. Folch. 2017. "Integration Of Liver Gene Co-Expression Networks And Egwas Analyses Highlighted Candidate Regulators Implicated In Lipid Metabolism In Pigs". Scientific Reports 7 (1). doi:10.1038/srep46539. 2045-2322 http://hdl.handle.net/20.500.12327/1738 https://doi.org/10.1038/srep46539 Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs