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oai:recercat.cat:20.500.12327/14442025-10-22T11:12:15Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Sibila, Marina author Rocco, Caterina author Franzo, Giovanni author Huerta, Eva author Domingo, Mariano author Núñez, José Ignacio author Segalés, Joaquim author 2021-08-12 Vaccination against porcine circovirus 2 (PCV-2) is a common practice all over the world. Vaccines can prevent PCV-2-systemic disease (PCV-2-SD) outbreaks but not PCV-2 infection, which can be detectable in a percentage of vaccinated animals. Occasionally, PCV-2-SD is diagnosed in vaccinated farms. The objective of this study was to genotype the PCV-2 strains detected in vaccinated animals diagnosed with PCV-2-SD. Additionally, the evolution of the frequency of PCV-2 genotype detection at Spanish, European, and world levels was assessed. Fifty cases diagnosed as PCV-2-SD between 2009 and 2020 were included in this study. PCV-2 genotype was determined by sequencing the Cap gene region. Among them, only PCV-2b (23/50, 46%) and PCV-2d (27/50, 54%) genotypes were detected. Although the frequency of detection of these two genotypes was similar, their temporal distribution was different. Whereas most PCV-2b sequences (17/23, 74%) were detected between 2009 and 2012, PCV-2d sequences were obtained from 2013 to 2020. Indeed, a predominance of the PCV-2d genotype was observed from 2013 onwards, a trend also noticed at European and world levels. The results suggest that detection of particular genotypes in vaccinated animals probably reflects the general prevalence of the genotypes over time rather than genotype-specific vaccine-immunity escaping. Sibila, Marina, Caterina Rocco, Giovanni Franzo, Eva Huerta, Mariano Domingo, José Ignacio Núñez, and Joaquim Segalés. 2021. "Genotyping Of Porcine Circovirus 2 (PCV-2) In Vaccinated Pigs Suffering From PCV-2-Systemic Disease Between 2009 And 2020 In Spain". Pathogens 10 (8): 1016. doi:10.3390/pathogens10081016. 2076-0817 http://hdl.handle.net/20.500.12327/1444 https://doi.org/10.3390/pathogens10081016 Genotyping of Porcine Circovirus 2 (PCV-2) in Vaccinated Pigs Suffering from PCV-2-Systemic Disease between 2009 and 2020 in Spain