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oai:recercat.cat:20.500.12327/14082025-10-22T11:22:01Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Llauradó-Calero, E. author Badiola, I. author Delpino-Rius, A. author Lizardo, R. author Torrallardona, D. author Esteve-Garcia, E. author Tous, T. author 2021-11-15 Colostrum and milk are the first nutrient sources for newborn piglets. In addition, n-3 fatty acids (FAs) and their oxygenated derivatives (oxylipins) have the capacity to modulate immune components. The aim of the current study was to include a fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in sow diets to promote an increase of anti-inflammatory molecules in colostrum and milk to benefit piglets. Thirty-six sows were randomly assigned from insemination to the end of lactation to either a control diet with animal fat (15 g/kg in gestation and 30 g/kg in lactation) or an n-3 diet in which animal fat was totally (gestation) or half (lactation) replaced by an equivalent amount of solid fish oil. Performance of sows and piglets was monitored during the study. Colostrum and milk samples were obtained after the birth of the first piglet and at weaning, respectively. From all samples (n = 18 per treatment), FAs were quantified by gas chromatography and immunoglobulins and cytokines by ELISA. Three samples per treatment were randomly selected to analyse oxylipin composition by liquid chromatography-tandem mass spectrometry. In colostrum and in milk, the n-3 FA (P = 0.020 and P < 0.001), particularly EPA (P < 0.001 and P < 0.001) and DHA (P < 0.001 and P < 0.001), and also their oxygenated derivatives were increased in samples from sows fed n-3 diet. Fish oil had no effect on immunoglobulin concentrations, but reduced tumour necrosis factor α (TNFα) (P = 0.011) and a tendency to reduce interleukin 10 (IL10) (P = 0.059) were observed in milk. In conclusion, fish oil in sow diets increased n-3 FA, particularly EPA and DHA, and their oxygenated derivatives in colostrum and milk, reducing TNFα and IL10 in milk. Llauradó-Calero, E., I. Badiola, A. Delpino-Rius, R. Lizardo, D. Torrallardona, E. Esteve-Garcia, and N. Tous. 2021. "Fish Oil Rich In Eicosapentaenoic Acid And Docosahexaenoic Acid In Sow Diets Modifies Oxylipins And Immune Indicators In Colostrum And Milk". Animal 15 (12): 100403. doi:10.1016/j.animal.2021.100403. 1751-7311 http://hdl.handle.net/20.500.12327/1408 https://doi.org/10.1016/j.animal.2021.100403 Fish oil rich in eicosapentaenoic acid and docosahexaenoic acid in sow diets modifies oxylipins and immune indicators in colostrum and milk