2026-04-14T03:01:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12327/13432025-10-22T11:30:22Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Brustolin, Marco author Rodon, Jordi author Rodríguez de la Concepción, María Luisa author Ávila-Nieto, Carlos author Cantero, Guillermo author Pérez, Mónica author Te, Nigeer author Noguera-Julián, Marc author Guallar, Víctor author Valencia, Alfonso author Roca, Núria author Izquierdo-Useros, Nuria author Blanco, Julià author Clotet, Bonaventura author Bensaid, Albert author Carrillo, Jorge author Serra Gironella, Joan author Segalés, Joaquim author 2021-04-29 Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease. Brustolin, Marco, Jordi Rodon, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Guillermo Cantero, Mónica Pérez, and Nigeer Te et al. 2021. "Protection Against Reinfection With D614- Or G614-SARS-Cov-2 Isolates In Golden Syrian Hamster". Emerging Microbes & Infections 10 (1): 797-809. doi:10.1080/22221751.2021.1913974. 2222-1751 http://hdl.handle.net/20.500.12327/1343 https://doi.org/10.1080/22221751.2021.1913974 Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster