2026-04-18T04:41:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:20.500.12327/11052025-10-22T11:18:18Zcom_2072_4428com_2072_4427col_2072_487898

00925njm 22002777a 4500 dc Vázquez-Gómez, Marta author Martín de Hijas-Villalba, Melani author Varona, Lluis author Ibañez-Escriche, Noelia author Rosas, Juan Pablo author Negro, Sara author Noguera, José Luis author Casellas, Joaquim author 2020-09-05 Transmission ratio distortion (TRD) is defined as the allele transmission deviation from the heterozygous parent to the offspring from the expected Mendelian genotypic frequencies. Although TRD can be a confounding factor in genetic mapping studies, this phenomenon remains mostly unknown in pigs, particularly in traditional breeds (i.e., the Iberian pig). We aimed to describe the maternal TRD prevalence and its genomic distribution in two Iberian varieties. Genotypes from a total of 247 families (dam and offspring) of Entrepelado (n = 129) and Retinto (n = 118) Iberian varieties were analyzed. The offspring were sired by both ungenotyped purebred Retinto and Entrepelado Iberian boars, regardless of the dam variety used. After quality control, 16,246 single-nucleotide polymorphisms (SNPs) in the Entrepelado variety and 9744 SNPs in the Retinto variety were analyzed. Maternal TRD was evaluated by a likelihood ratio test under SNP-by-SNP, adapting a previous model solved by Bayesian inference. Results provided 68 maternal TRD loci (TRDLs) in the Entrepelado variety and 24 in the Retinto variety (q < 0.05), with mostly negative TRD values, increasing the transmission of the minor allele. In addition, both varieties shared ten common TRDLs. No strong evidence of biological effects was found in genes with TRDLs. However, some biological processes could be affected by TRDLs, such as embryogenesis at different levels and lipid metabolism. These findings could provide useful insight into the genetic mechanisms to improve the swine industry, particularly in traditional breeds. Vázquez-Gómez, Marta, Melani Martín de Hijas-Villalba, Luis Varona, Noelia Ibañez-Escriche, Juan Pablo Rosas, Sara Negro, José Luis Noguera, and Joaquim Casellas. 2020. "Maternal Transmission Ratio Distortion In Two Iberian Pig Varieties". Genes 11 (9): 1050. doi:10.3390/genes11091050. 2073-4425 http://hdl.handle.net/20.500.12327/1105 https://doi.org/10.3390/genes11091050 Maternal Transmission Ratio Distortion in Two Iberian Pig Varieties