2026-04-14T07:02:15Zhttps://recercat.cat/oai/requestoai:recercat.cat:20.500.12327/10892025-10-22T11:34:14Zcom_2072_4428com_2072_4427col_2072_487898
RECERCAT
author
Baratelli, Massimiliano
author
Morgan, Sophie
author
Hemmink, Johanneke Dinie
author
Reid, Elizabeth
author
Carr, Brigid Veronica
author
Lefevre, Eric
author
Montaner-Tarbes, Sergio
author
Charleston, Bryan
author
Fraile, Lorenzo
author
Tchilian, Elma
author
Montoya, Maria
other
Producció Animal
group
Sanitat Animal
2025-10-22T11:34:14Z
2025-10-22T11:34:14Z
2020-09-16
Baratelli, Massimiliano, Sophie Morgan, Johanneke Dinie Hemmink, Elizabeth Reid, Brigid Veronica Carr, Eric Lefevre, and Sergio Montaner-Tarbes et al. 2020. "Identification Of A Newly Conserved SLA-II Epitope In A Structural Protein Of Swine Influenza Virus". Frontiers In Immunology 11. doi:10.3389/fimmu.2020.02083.
1664-3224
http://hdl.handle.net/20.500.12327/1089
https://doi.org/10.3389/fimmu.2020.02083
Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches either in outbred pigs or in Babraham large white inbred pigs, which are 85% identical by genome wide SNP analysis. On the other hand, some class II SLA epitopes were recently described in outbred pigs. In this work, Babraham large white inbred pigs were selected to identify SLA II epitopes from SwIV H1N1. PBMCs were screened for recognition of overlapping peptides covering the NP and M1 proteins from heterologous IAV H1N1 in IFNγ ELISPOT. A novel SLA class II restricted epitope was identified in NP from swine H1N1. This conserved novel epitope could be the base for further vaccine approaches against H1N1 in pigs.
eng
Attribution 4.0 International
Identification of a Newly Conserved SLA-II Epitope in a Structural Protein of Swine Influenza Virus
info:eu-repo/semantics/article