2026-04-13T07:15:34Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/98262024-12-13T09:17:26Zcom_2072_378070com_2072_378040com_2072_378071col_2072_378092col_2072_378097
RECERCAT
author
Salvà, Francesc
author
DOPAZO, CRISTINA
author
López, Daniel
author
Saoudi Gonzalez, Nadia
author
Charco, Ramon
author
Ros, Javier
author
Baraibar, Iosune
author
Tabernero, Josep
author
Elez, Elena
2023-11-08T10:21:49Z
2023-11-08T10:21:49Z
2023-06-21T07:36:10Z2023-06-21T07:36:10Z2023-05
http://hdl.handle.net/11351/9826
Liver transplantation; Metastatic colorectal cancerTrasplantament de fetge; Càncer colorectal metastàticTrasplante de hígado; Cáncer colorrectal metastásicoColorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients developing metastases to the liver. Five-year overall survival remains modest among patients with metastatic CRC (mCRC) treated with conventional therapies however, liver transplantation in a highly selected population can improve clinical outcomes with an impressive 5-year overall survival of 83%. Despite liver transplantation appearing to be a promising therapeutical option for well-selected patients with mCRC with the liver-limited disease, these data come from small monocentric trials which included a heterogeneous population. Currently, several clinical trials are evaluating liver transplantation in this scenario, aiming for a more accurate patient selection by integrating liquid biopsy, tissue profiling, and nuclear medicine to the already known clinical biomarkers that eventually may lead to a survival improvement. In this paper, the clinical outcomes and inclusion criteria from the most relevant clinical trials and clinical series involving liver transplantation in patients with liver-limited disease colorectal cancer are reviewed as well as the trials currently recruiting.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Fetge - Trasplantació
Còlon - Càncer
Recte - Càncer
Metàstasi
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Digestive System Surgical Procedures::Surgical Procedures, Operative::Surgical Procedures, Operative::Liver Transplantation
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::intervenciones quirúrgicas::intervenciones quirúrgicas::trasplante de hígado
Liver transplantation in metastatic colorectal cancer: are we ready for it?
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion