2026-04-17T06:25:45Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/98042025-10-24T10:25:18Zcom_2072_378070com_2072_378040col_2072_378092

The use of amino acid formulas in pediatric patients with allergy to cow’s milk proteins: Recommendations from a group of experts Ribes-Koninckx, Carmen Dias, Jorge Espin, Beatriz Molina Arias, Manuel Segarra, Oscar DIAZ MARTIN, JUAN JOSE Al·lèrgia alimentària Proteïnes de la llet Llet maternitzada Aminoàcids en la nutrició DISEASES::Immune System Diseases::Hypersensitivity::Hypersensitivity, Immediate::Food Hypersensitivity::Milk Hypersensitivity PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Beverages::Milk Substitutes::Infant Formula CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids Other subheadings::Other subheadings::Other subheadings::/administration & dosage ENFERMEDADES::enfermedades del sistema inmune::hipersensibilidad::hipersensibilidad inmediata::hipersensibilidad a los alimentos::hipersensibilidad a la leche FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::bebidas::sustitutivos de la leche::fórmulas infantiles Otros calificadores::Otros calificadores::Otros calificadores::/administración & dosificación COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos Amino acid formula; Cow’s milk allergy; Infant formula Fórmula d'aminoàcids; Al·lèrgia a la llet de vaca; Fórmula infantil Fórmula de aminoácidos; Alergia a la leche de vaca; Fórmula infantil One of the most common food allergies in children is cow’s milk allergy (CMA). In breast-fed infants with CMA, the mother is encouraged to avoid dairy products. If this is not possible, or in formula fed infants, use of hypoallergenic replacement formulas such as extensively hydrolyzed formulas (EHF) is recommended. However, in ∼5% of patients EHFs are not tolerated and/or allergy symptoms can persist. When EHFs are ineffective and in severe forms of CMA, amino acid-based formulas (AAF) should be considered. Six pediatric gastroenterologists with extensive experience in food allergy management reviewed scientific publications and international clinical practice guidelines to provide practical recommendations on AAF. The guidelines reviewed had discrepancies and ambiguities around the specific indications for using formulas as a milk substitute. The panel recommends AAFs as the first therapeutic option in anaphylaxis due to CMA, in acute and chronic severe food protein-induced enterocolitis syndrome, in CMA associated with multiple food allergy, and in cases of eosinophilic esophagitis not responding to an extended exclusion diet or not eating solids. The main benefit of AAF is its absence of residual allergenicity, making it a safe treatment option in severe CMA patients who do not tolerate or respond to an EHF. This research was funded by Nutricia to support the face-to-face and online meetings. 2025-10-24T10:25:18Z 2025-10-24T10:25:18Z 2025-10-24T10:25:18Z 2023-06-20T06:53:15Z 2023-06-20T06:53:15Z 2023-03-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/9804 Frontiers in Pediatrics;11 https://doi.org/10.3389/fped.2023.1110380 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Frontiers Media Scientia