2026-04-05T12:56:06Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/96802025-10-04T05:19:28Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Bernabé, R.
author
Diz, P.
author
González‑Larriba, J. L.
author
Lázaro, M.
author
Remon, Jordi
author
FELIP, ENRIQUETA
2023-06-07T11:59:59Z2023-06-07T11:59:59Z2022-04
Chemotherapy; Lenvatinib; Thymic epithelial tumoursQuimioterapia; lenvatinib; Tumores epiteliales tímicosQuimioteràpia; Lenvatinib; Tumors epitelials tímicsThymic epithelial tumours (TET) represent a heterogeneous group of rare malignancies that include thymomas and thymic carcinoma. Treatment of TET is based on the resectability of the tumour. If this is considered achievable upfront, surgical resection is the cornerstone of treatment. Platinum-based chemotherapy is the standard regimen for advanced TET. Due to the rarity of this disease, treatment decisions should be discussed in specific multidisciplinary tumour boards, and there are few prospective clinical studies with new strategies. However, several pathways involved in TET have been explored as potential targets for new therapies in previously treated patients, such as multi-tyrosine kinase inhibitors with antiangiogenic properties and immune checkpoint inhibitors (ICI). One third of patient with thymoma present an autoimmune disorders, increasing the risk of immune-related adverse events and autoimmune flares under ICIs. In these guidelines, we summarize the current evidence for the therapeutic approach in patients with TET and define levels of evidence for these decisions.
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
Decisió, Presa de
Epiteli - Càncer - Tractament
DISEASES::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Thymus Neoplasms
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial
Other subheadings::Other subheadings::Other subheadings::/drug therapy
HEALTH CARE::Health Services Administration::Patient Care Management::Disease Management
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del timo
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias glandulares y epiteliales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
ATENCIÓN DE SALUD::administración de los servicios de salud::gestión de la atención al paciente::tratamiento de las enfermedades
SEOM-GECP-GETTHI Clinical Guidelines for the treatment of patients with thymic epithelial tumours (2021)
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion