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oai:recercat.cat:11351/95722025-10-24T10:43:29Zcom_2072_378070com_2072_378040com_2072_451669col_2072_378092col_2072_451670

Falls Predict Acute Hospitalization in Parkinson's Disease de Deus Fonticoba, Teresa Cores Bartolomé, Carlos Suárez Castro, Ester Hernández Vara, Jorge Solano Vila, Berta JESUS MAESTRE, SILVIA Santos García, Diego Institut Català de la Salut [Santos García D, Cores C] Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain. [de Deus Fonticoba T, Suárez Castro E] Complexo Hospitalario Universitario de Ferrol, A Coruña, Spain. [Hernández Vara J] Departament de Neurologia i Recerca de Malalties Neurodegeneratives. Campus Universitari de la Vall D'Hebron, Barcelona, Spain. [Jesús S, Mir P] Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, CSIC, CIBERNED, Universidad de Sevilla, Sevilla, Spain. [Solano Vila B] Institut d'Assistència Sanitària, Institut Català de la Salut, Salt, Spain Institut d'Assistència Sanitària Parkinson, Malaltia de Dopa Models de riscos proporcionals de Cox DISEASES::Nervous System Diseases::Nervous System Diseases::Nervous System Diseases::Neurodegenerative Diseases::Parkinson Disease CHEMICALS AND DRUGS::Organic Chemicals::Amines::Catecholamines::Dihydroxyphenylalanine::Levodopa ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::aminas::catecolaminas::dihidroxifenilalanina::levodopa TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::modelos estadísticos::modelos de riesgos proporcionales Malaltia de Parkinson; Levodopa; Factors de risc Enfermedad de Parkinson; Levodopa; Factores de riesgo Parkinson Disease; Levodopa; Risk Factors Background:There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. Objective:To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort.Methods:PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit.Results:Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p = 0.035) was an independent predictor of AH. Conclusion:Falls is an independent predictor of AH in PD patients 2023-05-22T08:24:13Z 2023-05-22T08:24:13Z 2023-01-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Santos García D, de Deus Fonticoba T, Cores C, Suárez Castro E, Hernández Vara J, Jesús S, et al. Falls Predict Acute Hospitalization in Parkinson’s Disease. J Parkinsons Dis. 2023 Jan 31;13(1):105-24. 1877-718X https://hdl.handle.net/11351/9572 10.3233/JPD-212539 33843696 http://hdl.handle.net/11351/9572 eng Journal of Parkinson's Disease;13(1) https://dx.doi.org/10.3233/JPD-212539 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf IOS Press Scientia