2026-04-17T00:58:06Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/94582025-10-24T10:39:47Zcom_2072_378070com_2072_378040col_2072_378092

Anti-U11/U12 Antibodies as a Rare but Important Biomarker in Patients with Systemic Sclerosis: A Narrative Review Fritzler, Marvin Bentow, Chelsea Beretta, Lorenzo Palterer, Boaz Perurena-Prieto, Janire Sanz Martínez, María Teresa Guillén-Del-Castillo, Alfredo Marín-Sánchez, Ana Fonollosa Pla, Vicenç Simeón-Aznar , Carmen Pilar Marcadors bioquímics Factors antinuclears Esclerosi sistemàtica progressiva - Diagnòstic CHEMICALS AND DRUGS::Biological Factors::Biomarkers CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies, Antinuclear DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic Other subheadings::Other subheadings::/diagnosis COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos::anticuerpos antinucleares ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica Otros calificadores::Otros calificadores::/diagnóstico Autoantibodies; Interstitial lung disease; Systemic sclerosis Autoanticuerpos; Enfermedad pulmonar intersticial; Esclerosis sistémica Autoanticossos; Malaltia pulmonar intersticial; Esclerosi sistèmica Anti-nuclear (ANA) are present in approximately 90% of systemic sclerosis (SSc) patients and are key biomarkers in supporting the diagnosis and determining the prognosis of this disease. In addition to the classification criteria autoantibodies for SSc [i.e., anti-centromere, anti-topoisomerase I (Scl-70), anti-RNA polymerase III], other autoantibodies have been associated with important SSc phenotypes. Among them, anti-U11/U12 ribonucleoprotein (RNP) antibodies, also known as anti-RNPC-3, were first reported in a patient with SSc, but very little is known about their association and clinical utility. The U11/U12 RNP macromolecular complex consists of several proteins involved in alternative mRNA splicing. More recent studies demonstrated associations of anti-anti-U11/U12 antibodies with SSc and severe pulmonary fibrosis as well as with moderate to severe gastrointestinal dysmotility. Lastly, anti-U11/U12 autoantibodies have been strongly associated with malignancy in SSc patients. Here, we aimed to summarize the knowledge of anti-U11/U12/RNPC-3 antibodies in SSc, including their seroclinical associations in a narrative literature review. 2025-10-24T10:39:47Z 2025-10-24T10:39:47Z 2025-10-24T10:39:47Z 2023-05-04T11:47:45Z 2023-05-04T11:47:45Z 2023-03-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/9458 Diagnostics;13(7) https://doi.org/10.3390/diagnostics13071257 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess MDPI Scientia