2026-04-17T17:32:29Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/94202024-11-01T03:00:12Zcom_2072_378071com_2072_378040col_2072_378097

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection González Robles, Alba Rey Cano, Joan Esperalba Esquerra, Juliana Falcó Ferrer, Vicenç Buzón Gómez, María José Genesca Ferrer, Meritxell González Kuguel, Sebastián Rosado Rodríguez, Joel Pieren, Daan Mancebo Pérez, Cristina COVID-19 (Malaltia) - Vacunació Cèl·lules T Immunoglobulines ANATOMY::Hemic and Immune Systems::Blood::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Hemic and Immune Systems::T-Lymphocytes DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Viral PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Adaptive Immunity::Immunologic Memory ANATOMÍA::sistemas sanguíneo e inmunológico::sangre::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::sistemas sanguíneo e inmunológico::linfocitos T ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos víricos FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad adaptativa::memoria inmunológica SARS-CoV-2; T cells; Vaccines SARS-CoV-2; Células T; Vacunas SARS-CoV-2; Cèl·lules T; Vacunes Resident memory T cells (TRM) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting viral infection and disease. While long-term antigen-specific TRM are detectable beyond 11 months in the lung of convalescent COVID-19 patients, it is unknown if mRNA vaccination encoding for the SARS-CoV-2 S-protein can induce this frontline protection. Here we show that the frequency of CD4+ T cells secreting IFNγ in response to S-peptides is variable but overall similar in the lung of mRNA-vaccinated patients compared to convalescent-infected patients. However, in vaccinated patients, lung responses present less frequently a TRM phenotype compared to convalescent infected individuals and polyfunctional CD107a+ IFNγ+ TRM are virtually absent in vaccinated patients. These data indicate that mRNA vaccination induces specific T cell responses to SARS-CoV-2 in the lung parenchyma, although to a limited extend. It remains to be determined whether these vaccine-induced responses contribute to overall COVID-19 control. This work was supported by grants from Fundació La Marató TV3 (201814-10 FMTV3 and 202112-30 FMTV3, M.G.), from the Health department of the Government of Catalonia (DGRIS 1_5, to M.G. and M.J.B). M.J.B. is supported by the Miguel Servet program funded by the Spanish Health Institute Carlos III (CP17/00179). 2023-04-26T09:21:21Z 2023-04-26T09:21:21Z 2023-04-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nature Communications;14 https://doi.org/10.1038/s41467-023-37559-w Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Springer Nature Scientia