2026-04-17T19:16:50Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/93882025-10-24T08:28:48Zcom_2072_451660com_2072_378040col_2072_451662

Incidence, Clinical Characteristics, Risk Factors and Outcomes of Acute Coronary Syndrome in Patients With COVID-19: Results of the UMC-19-S10 Alquézar, Aitor Jiménez Hernández, Sònia Martín Martínez. Alfonso Llorens-Soriano, Pere Martín Martínez, Alfonso Gonzalez del Castillo, Juan Tost, Josep Miro Andreu, Oscar COVID-19 (Malaltia) Cor - Malalties DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections DISEASES::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Acute Coronary Syndrome ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus ENFERMEDADES::enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::síndrome coronario agudo COVID-19; SARS-Cov-2; Síndrome coronari agut COVID-19; SARS-Cov-2; Síndrome coronario agudo COVID-19; SARS-Cov-2; Acute coronary syndrome Background: There is a lack of knowledge about the real incidence of acute coronary syndrome (ACS) in patients with COVID-19, their clinical characteristics, and their prognoses. Objective: We investigated the incidence, clinical characteristics, risk factors, and outcomes of ACS in patients with COVID-19 in the emergency department. Methods: We retrospectively reviewed all COVID-19 patients diagnosed with ACS in 62 Spanish emergency departments between March and April 2020 (the first wave of COVID-19). We formed 2 control groups: COVID-19 patients without ACS (control A) and non-COVID-19 patients with ACS (control B). Unadjusted comparisons between cases and control subjects were performed regarding 58 characteristics and outcomes. Results: We identified 110 patients with ACS in 74,814 patients with COVID-19 attending the ED (1.48% [95% confidence interval {CI} 1.21-1.78%]). This incidence was lower than that observed in non-COVID-19 patients (3.64% [95% CI 3.54-3.74%]; odds ratio [OR] 0.40 [95% CI 0.33-0.49]). The clinical characteristics of patients with COVID-19 associated with a higher risk of presenting ACS were: previous coronary artery disease, age ≥60 years, hypertension, chest pain, raised troponin, and hypoxemia. The need for hospitalization and admission to intensive care and in-hospital mortality were higher in cases than in control group A (adjusted OR [aOR] 6.36 [95% CI 1.84-22.1], aOR 4.63 [95% CI 1.88-11.4], and aOR 2.46 [95% CI 1.15-5.25]). When comparing cases with control group B, the aOR of admission to intensive care was 0.41 (95% CI 0.21-0.80), while the aOR for in-hospital mortality was 5.94 (95% CI 2.84-12.4). Conclusions: The incidence of ACS in patients with COVID-19 attending the emergency department was low, around 1.48%, but could be increased in some circumstances. Patients with COVID-19 with ACS had a worse prognosis than control subjects with higher in-hospital mortality 2025-10-24T08:28:48Z 2025-10-24T08:28:48Z 2025-10-24T08:28:48Z 2023-04-21T12:48:43Z 2023-04-21T12:48:43Z 2022-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/9388 The Journal of Emergency Medicine;62(4) https://doi.org/10.1016/j.jemermed.2021.10.046 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Elsevier Scientia