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oai:recercat.cat:11351/92132025-10-24T10:27:49Zcom_2072_378070com_2072_378040col_2072_378092

The role of high serum triglyceride levels on pancreatic necrosis development and related complications Hidalgo, Nils Jimmy Pando, Elizabeth Alberti Delgado, Piero Mata Mata, Rodrigo José Fernandes Montes, Nair Sonia Adell Trapé, Montse Villasante, Sara Charco, Ramon Balsells Valls, Joaquim Blanco Cuso, Laia Institut Català de la Salut [Hidalgo NJ, Pando E] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Alberti P, Mata R, Fernandes N, Adell M, Villasante S, Blanco L, Balsells J, Charco R] Servei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d’Hebron Hospital Universitari, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Pàncrees - Necrosi Pancreatitis Hipertriacilgliceridèmia DISEASES::Digestive System Diseases::Pancreatic Diseases::Pancreatitis::Pancreatitis, Acute Necrotizing DISEASES::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypertriglyceridemia ENFERMEDADES::enfermedades del sistema digestivo::enfermedades pancreáticas::pancreatitis::pancreatitis aguda necrotizante ENFERMEDADES::enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de los lípidos::dislipidemias::hiperlipidemias::hipertrigliceridemia Acute pancreatitis; Pancreatic necrosis; Triglyceride Pancreatitis aguda; Necrosi pancreàtica; Triglicèrids Pancreatitis aguda; Necrosis pancreática; Triglicéridos Background The relevance of elevated serum triglyceride (TG) levels in the early stages of acute pancreatitis (AP) not induced by hypertriglyceridemia (HTG) remains unclear. Our study aims to determine the role of elevated serum TG levels at admission in developing pancreatic necrosis. Methods We analyzed the clinical data collected prospectively from patients with AP. According to TG levels measured in the first 24 h after admission, we stratified patients into four groups: Normal TG (< 150 mg/dL), Borderline-high TG (150–199 mg/dL), High TG (200–499 mg/dL) and Very high TG (≥ 500 mg/dL). We analyzed the association of TG levels and other risk factors with the development of pancreatic necrosis. Results A total of 211 patients were included. In the Normal TG group: 122, in Borderline-high TG group: 38, in High TG group: 44, and in Very high TG group: 7. Pancreatic necrosis developed in 29.5% of the patients in the Normal TG group, 26.3% in the Borderline-high TG group, 52.3% in the High TG group, and 85.7% in the Very high TG group. The trend analysis observed a significant association between higher TG levels and pancreatic necrosis (p = 0.001). A multivariable analysis using logistic regression showed that elevated TG levels ≥ 200 mg/dL (High TG and Very high TG groups) were independently associated with pancreatic necrosis (OR: 3.27, 95% CI − 6.27, p < 0.001). Conclusions An elevated TG level at admission ≥ 200 mg/dl is independently associated with the development of pancreatic necrosis. The incidence of pancreatic necrosis increases proportionally with the severity of HTG. 2023-03-21T09:26:12Z 2023-03-21T09:26:12Z 2023-02-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hidalgo NJ, Pando E, Alberti P, Mata R, Fernandes N, Adell M, et al. The role of high serum triglyceride levels on pancreatic necrosis development and related complications. BMC Gastroenterol. 2023 Feb 24;23:51. 1471-230X https://hdl.handle.net/11351/9213 10.1186/s12876-023-02684-9 36829113 000939366600002 http://hdl.handle.net/11351/9213 eng BMC Gastroenterology;23 https://doi.org/10.1186/s12876-023-02684-9 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf application/pdf BMC Scientia