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oai:recercat.cat:11351/90772026-04-04T03:14:37Zcom_2072_378070com_2072_378040col_2072_378092

Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting Roade Tato, Maria Luisa Sulleiro Igual, Elena Bocanegra García, Maria Cristina Goterris Bonet, Lidia Serre Delcor, Nuria Oliveira Souto, Ines Mercedes Aznar Ruiz de Alegria, Maria Luisa Sánchez Montalvá, Adrián Bosch Nicolau, Pau Espinosa Pereiro, Juan Pou Ciruelo, Diana Zarzuela Serrat, Francesc Treviño Maruri, Begoña Molina Romero, Israel Salvador Velez, Fernando M Institut Català de la Salut [Roade L] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Sulleiro E, Zarzuela F, Goterris L] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain. [Bocanegra C, Salvador F, Treviño B, Serre-Delcor N, Oliveira-Souto I, Aznar ML, Pou D, Sánchez-Montalvà A, Bosch-Nicolau P, Espinosa-Pereiro J, Molina I] Unitat de Medicina Tropical i Salut Internacional Drassanes-Vall d'Hebron Hospital Universitari, Barcelona, Spain. Servei de Malalties Infeccioses, Vall d'Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Cribatge (Medicina) Esquistosomiasi - Diagnòstic Malalties transmissibles DISEASES::Parasitic Diseases::Helminthiasis::Trematode Infections::Schistosomiasis Other subheadings::Other subheadings::/diagnosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Mass Screening DISEASES::Bacterial Infections and Mycoses::Infection::Communicable Diseases ENFERMEDADES::enfermedades parasitarias::helmintiasis::infecciones por trematodos::esquistosomiasis Otros calificadores::Otros calificadores::/diagnóstico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::cribado sistemático ENFERMEDADES::infecciones bacterianas y micosis::infección::enfermedades transmisibles Diagnosis; Non-endemic; Schistosomiasis Diagnóstico; No endémico; Esquistosomiasis Diagnòstic; No endèmic; Esquistosomiasi A consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. A retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: (A) feces and urine direct examination plus S. mansoni serology if non-explained eosinophilia was present and (B) S. mansoni serology plus uroparasitological examination as the second step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and a 24 month follow-up were recorded for each group. Four-hundred forty individuals were included. The patients were mainly from West African countries. Fifty schistosomiasis cases were detected (11.5% group A vs. 4 % group B, p = 0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.4% (16/88). Schistosomiasis cases were younger (p < 0.001) and presented eosinophilia and elevated IgE (p < 0.001) more frequently. Schistosomiasis is a frequent diagnosis among high-risk populations. Serology achieves a similar performance to direct diagnosis for the screening of schistosomiasis in a high-risk population. 2023-03-01T11:23:42Z 2023-03-01T11:23:42Z 2023-01-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Roade L, Sulleiro E, Bocanegra C, Salvador F, Treviño B, Zarzuela F, et al. Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting. Trop Med Infect Dis. 2023 Jan 6;8(1):44. 2414-6366 https://hdl.handle.net/11351/9077 10.3390/tropicalmed8010044 36668951 eng Tropical Medicine and Infectious Disease;8(1) https://doi.org/10.3390/tropicalmed8010044 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess application/pdf MDPI Scientia