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oai:recercat.cat:11351/89372025-10-24T10:18:50Zcom_2072_378070com_2072_378040col_2072_378092

Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis: A cohort study Rivière, Amélie Picard, Clément Mora Cuesta, Víctor Manuel Bunel, Vincent Godinas, Laurent Berastegui Garcia, Cristina Institut Català de la Salut [Rivière A] Service de Pneumologie, Hôpital Avicenne (AP-HP), Université Sorbonne Paris Nord, Bobigny, France. [Picard C] Service de Transplantation Pulmonaire et Centre de Compétence de la Mucoviscidose, Hôpital Foch, Suresnes, France. [Berastegui C] Servei de Pneumologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Mora VM] Lung Transplant Unit, Department of Respiratory Medicine, H. Marqués de Valdecilla, Santander, Spain. [Bunel V] Service de Pneumologie, Hôpital Bichat (AP-HP), Paris, France. [Godinas L] Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium Vall d'Hebron Barcelona Hospital Campus Pulmons - Trasplantació Pulmons - Malalties Músculs - Malalties ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Thoracic Surgical Procedures::Pulmonary Surgical Procedures::Lung Transplantation DISEASES::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Interstitial Other subheadings::Other subheadings::Other subheadings::/surgery DISEASES::Nervous System Diseases::Neuromuscular Diseases::Muscular Diseases::Myositis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos torácicos::procedimientos quirúrgicos pulmonares::trasplante de pulmón ENFERMEDADES::enfermedades respiratorias::enfermedades pulmonares::enfermedades pulmonares intersticiales Otros calificadores::Otros calificadores::Otros calificadores::/cirugía ENFERMEDADES::enfermedades del sistema nervioso::enfermedades neuromusculares::enfermedades musculares::miositis Connective tissue disease; Idiopathic inflammatory myopathy; Interstitial lung disease Enfermedad del tejido conectivo; Miopatía inflamatoria idiopática; Enfermedad pulmonar intersticial Malaltia del teixit conjuntiu; Miopatia inflamatòria idiopàtica; Malaltia pulmonar intersticial In patients with interstitial lung disease (ILD) complicating classical or amyopathic idio-pathic inflammatory myopathy (IIM), lung transplantation outcomes might be affected by the disease and treatments. Here, our objective was to assess survival and prog-nostic factors in lung transplant recipients with IIM-ILD. We retrospectively reviewed data for 64 patients who underwent lung transplantation between 2009 and 2021 at 19 European centers. Patient survival was the primary outcome. At transplantation, the median age was 53 [46–59] years, 35 (55%) patients were male, 31 (48%) had clas-sical IIM, 25 (39%) had rapidly progressive ILD, and 21 (33%) were in a high- priority transplant allocation program. Survival rates after 1, 3, and 5 years were 78%, 73%, and 70%, respectively. During follow-up (median, 33 [7–63] months), 23% of patients developed chronic lung allograft dysfunction. Compared to amyopathic IIM, classical IIM was characterized by longer disease duration, higher-intensity immunosuppres-sion before transplantation, and significantly worse posttransplantation survival. Five (8%) patients had a clinical IIM relapse, with mild manifestations. No patient expe-rienced ILD recurrence in the allograft. Posttransplantation survival in IIM-ILD was similar to that in international all- cause- transplantation registries. The main factor as-sociated with worse survival was a history of muscle involvement (classical IIM). In lung transplant recipients with idiopathic inflammatory myopathy, survival was similar to that in all-cause transplantation and was worse in patients with muscle involvement compared to those with the amyopathic disease. 2023-01-31T12:07:42Z 2023-01-31T12:07:42Z 2022-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rivière A, Picard C, Berastegui C, Mora VM, Bunel V, Godinas L, et al. Lung transplantation for interstitial lung disease in idiopathic inflammatory myositis: A cohort study. Am J Transplant. 2022 Dec;22(12):2990–3001. 1600-6143 https://hdl.handle.net/11351/8937 10.1111/ajt.17177 35988032 000849580500001 http://hdl.handle.net/11351/8937 eng American Journal of Transplantation;22(12) https://doi.org/10.1111/ajt.17177 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf Wiley Scientia