2026-04-13T07:22:52Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/88102025-10-24T10:42:45Zcom_2072_378070com_2072_378040col_2072_378092

Switching Clozapine to Cariprazine in Three Patients with Persistent Symptoms of Schizophrenia: A Case Series Avila, Juan Carlos Duque-Yemail, Juan D Esquizofrènia - Tractament Antipsicòtics - Ús terapèutic PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Schizophrenia Spectrum and Other Psychotic Disorders::Schizophrenia Other subheadings::Other subheadings::Other subheadings::/drug therapy CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Central Nervous System Depressants::Tranquilizing Agents::Antipsychotic Agents Other subheadings::Other subheadings::/therapeutic use PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::espectro de la esquizofrenia y otros trastornos psicóticos::esquizofrenia Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::efectos fisiológicos de los fármacos::depresores del sistema nervioso central::tranquilizantes::antipsicóticos Otros calificadores::Otros calificadores::/uso terapéutico Atypical antipsychotics; Cariprazine; Resistant schizophrenia Antipsicóticos atípicos; Cariprazina; Esquizofrenia resistente Antipsicòtics atípics; Cariprazina; Esquizofrènia resistent Despite many available treatments for schizophrenia, several unmet needs persist in treating individuals with this disorder, and the response rate to first-line antipsychotics remains relatively low. Clozapine has shown efficacy in treating schizophrenia patients who failed to respond to previous antipsychotics. However, side effects and the need for routine blood tests have limited its use as a first-line treatment. Cariprazine is a D2/D3 partial agonist antipsychotic with a mechanism of action that differs from other antipsychotics due to its higher affinity for D3 receptors. Several trials have demonstrated the efficacy of cariprazine on positive and negative symptoms of schizophrenia and have shown that it is a well-tolerated treatment. In this series, we present 3 cases of patients diagnosed with schizophrenia who were initially under treatment with clozapine. Despite some initial improvement, the patients showed persisting positive and negative symptoms or developed limiting side effects while in treatment with clozapine. Cariprazine treatment was titrated concurrently with clozapine tapering until its discontinuation. Significant improvement in both positive and negative symptoms was observed up to 14 months after starting cariprazine, and resolution of side effects was reported in all cases. Our case series supports cariprazine as an effective treatment for positive and negative symptoms in patients who failed to adequately respond or poorly tolerated treatment with clozapine, as well as a potential treatment in dual disorders, specifically psychotic disorders and cocaine use disorder. 2025-10-24T10:42:45Z 2025-10-24T10:42:45Z 2025-10-24T10:42:45Z 2023-01-12T07:17:25Z 2023-01-12T07:17:25Z 2022-07-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/8810 Neuropsychiatric Disease and Treatment;18 https://doi.org/10.2147/NDT.S367922 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess Dove Medical Press Scientia