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Mechanical thrombectomy with a novel device: initial clinical experience with the ANA thrombectomy device Tomasello Weitz, Alejandro Requena Ruiz, Manuel Liebeskind, David Ribó Jacobi, Marc Hernandez Morales, David Piñana Plaza, Carlos Nogueira, Raul Institut Català de la Salut [Tomasello A, Hernandez D, Piñana C] Servei de Neuroradiologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Requena M, Ribo M] Unitat d’Ictus, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Liebeskind DS] Neurovascular Imaging Research Core and University of California Los Angeles Stroke Center, Department of Neurology, University of California, Los Angeles, CA, USA. [Nogueira RG] Department of Neurology, Neurosurgery and Radiology, Emory University School of Medicine, Atlanta, GA, USA Vall d'Hebron Barcelona Hospital Campus Vasos sanguinis - Cirurgia Malalties cerebrovasculars Avaluació de resultats (Assistència sanitària) ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Thrombectomy::Mechanical Thrombolysis DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos cardiovasculares::procedimientos quirúrgicos vasculares::trombectomía::trombólisis mecánica ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento Mechanical thrombectomy; New device; Stroke Trombectomia mecànica; Nou dispositiu; Ictus Trombectomía mecánica; Nuevo dispositivo; Ictus Introduction The ANA™ (Anaconda Biomed) thrombectomy system is a novel stroke thrombectomy device comprising a self-expanding funnel designed to reduce clot fragmentation by locally restricting flow while becoming as wide as the lodging artery. Once deployed, ANA allows distal aspiration in combination with a stentretriever (SR) to mobilize the clot into the funnel where it remains copped during extraction. We investigate safety and efficacy of ANA™ in a first-in-man study. Methods Prospective data was collected on 35 consecutive patients treated as first line with ANA™ at a single centre. Outcome measures included per-pass reperfusion scores, symptomatic intracerebral hemorrhage (sICH), NIHSS at day 5, and mRS at 90 days. Results Median NIHSS was 12(9−18). Sites of primary occlusion were: 5 ICA, 15 M1-MCA, 15 M2-MCA. Primary performance endpoint, mTICI 2b-3 within 3 passes without rescue therapy was achieved in 91.4% (n = 32) of patients; rate of complete recanalization (mTICI 2c-3) was 65.7%. First pass complete recanalization rate was 42.9%, and median number of ANA passes 1(IQR: 1−2). In 17.1% (n = 6) rescue treatment was used; median number of rescue passes was 2(1–7), leading to a final mTICI2b-3rate of 94.3% (n = 33). There were no device related serious adverse events, and rate of sICH was 5.7% (n = 2). At 5 days median NIHSS was 1 (IQR 1−6) and 90 days mRS 0−2 was achieved in 60% of patients. Conclusions In this initial clinical experience, the ANA™ device achieved a high rate of complete recanalization with a good safety profile and favourable 90 days clinical outcomes. The study was funded by Anaconda Biomed S.L. 2023-01-10T08:27:40Z 2023-01-10T08:27:40Z 2022-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Tomasello A, Hernandez D, Piñana C, Requena M, Liebeskind DS, Nogueira RG, et al. Mechanical thrombectomy with a novel device: initial clinical experience with the ANA thrombectomy device. J Neuroradiol. 2022 Jun;49(4):324–8. 1773-0406 https://hdl.handle.net/11351/8796 10.1016/j.neurad.2020.11.003 33340641 000818010600004 http://hdl.handle.net/11351/8796 eng Journal of Neuroradiology;49(4) https://doi.org/10.1016/j.neurad.2020.11.003 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess application/pdf Elsevier Scientia