2026-04-13T07:22:37Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/87962025-10-24T10:21:53Zcom_2072_378070com_2072_378040col_2072_378092
RECERCAT
author
Tomasello Weitz, Alejandro
author
Requena Ruiz, Manuel
author
Liebeskind, David
author
Ribó Jacobi, Marc
author
Hernandez Morales, David
author
Piñana Plaza, Carlos
author
Nogueira, Raul
2025-10-24T10:21:52Z
2025-10-24T10:21:52Z
2023-01-10T08:27:40Z2023-01-10T08:27:40Z2022-06
http://hdl.handle.net/11351/8796
Mechanical thrombectomy; New device; StrokeTrombectomia mecànica; Nou dispositiu; IctusTrombectomía mecánica; Nuevo dispositivo; IctusIntroduction
The ANA™ (Anaconda Biomed) thrombectomy system is a novel stroke thrombectomy device comprising a self-expanding funnel designed to reduce clot fragmentation by locally restricting flow while becoming as wide as the lodging artery. Once deployed, ANA allows distal aspiration in combination with a stentretriever (SR) to mobilize the clot into the funnel where it remains copped during extraction. We investigate safety and efficacy of ANA™ in a first-in-man study.
Methods
Prospective data was collected on 35 consecutive patients treated as first line with ANA™ at a single centre. Outcome measures included per-pass reperfusion scores, symptomatic intracerebral hemorrhage (sICH), NIHSS at day 5, and mRS at 90 days.
Results
Median NIHSS was 12(9−18). Sites of primary occlusion were: 5 ICA, 15 M1-MCA, 15 M2-MCA. Primary performance endpoint, mTICI 2b-3 within 3 passes without rescue therapy was achieved in 91.4% (n = 32) of patients; rate of complete recanalization (mTICI 2c-3) was 65.7%. First pass complete recanalization rate was 42.9%, and median number of ANA passes 1(IQR: 1−2). In 17.1% (n = 6) rescue treatment was used; median number of rescue passes was 2(1–7), leading to a final mTICI2b-3rate of 94.3% (n = 33). There were no device related serious adverse events, and rate of sICH was 5.7% (n = 2). At 5 days median NIHSS was 1 (IQR 1−6) and 90 days mRS 0−2 was achieved in 60% of patients.
Conclusions
In this initial clinical experience, the ANA™ device achieved a high rate of complete recanalization with a good safety profile and favourable 90 days clinical outcomes.The study was funded by Anaconda Biomed S.L.
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
Vasos sanguinis - Cirurgia
Malalties cerebrovasculars
Avaluació de resultats (Assistència sanitària)
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Surgical Procedures, Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Thrombectomy::Mechanical Thrombolysis
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Stroke
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::intervenciones quirúrgicas::procedimientos quirúrgicos cardiovasculares::procedimientos quirúrgicos vasculares::trombectomía::trombólisis mecánica
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::accidente cerebrovascular
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
Mechanical thrombectomy with a novel device: initial clinical experience with the ANA thrombectomy device
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion