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oai:recercat.cat:11351/86162024-12-13T10:45:11Zcom_2072_378070com_2072_378040col_2072_378092

Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study Pedersen, Frederik Nørregaard Stokholm, Lonny Pouwer, Frans Rubin, Katrine Hass Peto, Tunde Frydkjaer-Olsen, Ulrik Simó Canonge, Rafael Institut Català de la Salut [Pedersen FN] Department of Ophthalmology, Odense University Hospital, Odense, Denmark. Department of Clinical Research, University of Southern Denmark, Odense, Denmark. [Stokholm L, Hass Rubin K] Department of Clinical Research, University of Southern Denmark, Odense, Denmark. OPEN – Open Patient Data Explorative Network, Odense University Hospital & University of Southern Denmark, Odense, Denmark. [Pouwer F] Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Department of Psychology, University of Southern Denmark, Odense, Denmark. [Peto T] Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, Northern Ireland, UK. [Frydkjær-Olsen U] Department of Ophthalmology, Lillebaelt Hospital, Vejle, Denmark. [Simó R] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERDEM (ISCIII), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus Retinopatia diabètica Alzheimer, Malaltia d' - Factors de Risc - Dinamarca DISEASES::Eye Diseases::Retinal Diseases::Diabetic Retinopathy DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors GEOGRAPHICALS::Geographic Locations::Europe::Scandinavian and Nordic Countries::Denmark ENFERMEDADES::oftalmopatías::enfermedades de la retina::retinopatía diabética ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo DENOMINACIONES GEOGRÁFICAS::localizaciones geográficas::Europa (continente)::Escandinavia::Dinamarca Cognitive impairment; Diabetes mellitus; Diabetic retinopathy Discapacidad cognitiva; Diabetes mellitus; Retinopatía diabética Discapacitat cognitiva; Diabetis mellitus; Retinopatia diabètica Background: Retinal neurodegeneration is evident in early diabetic retinopathy (DR) which may be associated with other neurodegenerative diseases like Alzheimer's disease (AD). Objective: To investigate diabetes and DR as a risk marker of present and incident AD. Methods: A register-based cohort study was performed. We included 134,327 persons with diabetes above 60 years of age, who had attended DR screening, and 651,936 age- and gender-matched persons without diabetes. Results: At baseline, the prevalence of AD was 0.7% and 1.3% among patients with and without diabetes, respectively. In a multivariable regression model, patients with diabetes were less likely to have AD at baseline (adjusted OR 0.63, 95% CI 0.59–0.68). During follow-up, incident AD was registered for 1473 (0.35%) and 6,899 (0.34%) persons with and without diabetes, respectively. Compared to persons without diabetes, persons with diabetes and no DR had a lower risk to develop AD (adjusted HR 0.87, 95% CI 0.81–0.93), while persons with diabetes and DR had higher risk of AD (adjusted HR 1.24, 95% CI 1.08–1.43). When persons with diabetes and no DR were used as references, a higher risk of incident AD was observed in persons with DR (adjusted HR 1.34, 95% CI 1.18–1.53). Conclusion: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR. This work was supported by VELUX FONDEN (grant number 00028744) and Odense University Hospital PhD Foundation (grant number 4339). 2022-12-09T09:03:28Z 2022-12-09T09:03:28Z 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pedersen FN, Stokholm L, Pouwer F, Hass Rubin K, Peto T, Frydkjær-Olsen U, et al. Diabetic Retinopathy Predicts Risk of Alzheimer’s Disease: A Danish Registry-Based Nationwide Cohort Study. J Alzheimers Dis. 2022;86:451–60. 1387-2877 https://hdl.handle.net/11351/8616 10.3233/JAD-215313 35068460 000768536700028 http://hdl.handle.net/11351/8616 eng Journal of Alzheimer's Disease;86 http://dx.doi.org/10.3233/JAD-215313 Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess application/pdf IOS Press Scientia