2026-04-13T02:10:44Zhttps://recercat.cat/oai/request

oai:recercat.cat:11351/82562024-12-13T09:26:34Zcom_2072_378071com_2072_378040col_2072_378097

2023-11-08T15:23:55Z urn:hdl:11351/8256 Effectiveness of interventions to improve medication adherence in adults with depressive disorders: a meta-analysis González de León, Beatriz del Pino-Sedeno, Tasmania Serrano Pérez, Pedro Rodríguez-Alvarez, Cristobalina Bejarano-Quisoboni, Daniel Trujillo‑Martín, María M. Antidepressius - Ús terapèutic Pacients - Cooperació Depressió psíquica - Tractament PSYCHIATRY AND PSYCHOLOGY::Behavior and Behavior Mechanisms::Attitude::Attitude to Health::Treatment Adherence and Compliance::Patient Acceptance of Health Care::Patient Compliance::Medication Adherence PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, Major CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Psychotropic Drugs::Antidepressive Agents Other subheadings::Other subheadings::/therapeutic use PSIQUIATRÍA Y PSICOLOGÍA::conducta y mecanismos de la conducta::actitud::actitud ante la salud::cumplimiento y adherencia al tratamiento::aceptación de la asistencia sanitaria por parte del paciente::cumplimiento del paciente::adhesión a la medicación PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del humor::trastorno depresivo::trastorno depresivo mayor COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::fármacos psicotrópicos::antidepresivos Otros calificadores::Otros calificadores::/uso terapéutico Trastorno depresivo mayor; Metanálisis; Adherencia al tratamiento Trastorn depressiu major; Metaanàlisi; Adherència al tractament Major depressive disorder; Meta-analysis; Treatment adherence Background Non-adherence to medication is a major obstacle in the treatment of depressive disorders. We systematically reviewed the literature to evaluate the effectiveness of interventions aimed at improving adherence to medication among adults with depressive disorders with emphasis on initiation and implementation phase. Methods We searched Medline, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, Social Science Citation Index and Science Citation Index for randomized or non-randomized controlled trials up to January 2022. Risk of bias was assessed using the criteria of the Cochrane Collaboration. Meta-analyses, cumulative and meta-regression analyses for adherence were conducted. Results Forty-six trials (n = 24,324) were included. Pooled estimate indicates an increase in the probability of adherence to antidepressants at 6 months with the different types of interventions (OR 1.33; 95% CI: 1.09 to 1.62). The improvement in adherence is obtained from 3 months (OR 1.62, 95% CI: 1.25 to 2.10) but it is attenuated at 12 months (OR 1.25, 95% CI: 1.02 to 1.53). Selected articles show methodological differences, mainly the diversity of both the severity of the depressive disorder and intervention procedures. In the samples of these studies, patients with depression and anxiety seem to benefit most from intervention (OR 2.77, 95% CI: 1.74 to 4.42) and collaborative care is the most effective intervention to improve adherence (OR 1.88, 95% CI: 1.40 to 2.54). Conclusions Our findings indicate that interventions aimed at improving adherence to medication among adults with depressive disorders are effective up to six months. However, the evidence on the effectiveness of long-term adherence is insufficient and supports the need for further research efforts. This study has been funded by Instituto de Salud Carlos III through the project "PI18/00767" (Co-funded by European Regional Development Fund/European Social Fund "A way to make Europe"/"Investing in your future"). 2023-11-08T15:23:55Z 2023-11-08T15:23:55Z 2022-10-05T07:11:25Z 2022-10-05T07:11:25Z 2022-07-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/11351/8256 BMC Psychiatry;22 https://doi.org/10.1186/s12888-022-04120-w Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess BMC Scientia