2026-04-17T19:22:19Zhttps://recercat.cat/oai/requestoai:recercat.cat:11351/81732025-10-24T10:59:16Zcom_2072_451665com_2072_378040col_2072_451666
SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis
Jesús Gil, Carmen de
García-Jiménez, Irene
Sans De San Nicolàs, Lídia
Figueras, Ignasi
Guilabert, Antonio
Bonfill Ortí, Montserrat
Dermatitis atòpica
Estafilococs daurats
Pell - Infeccions
DISEASES::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis::Skin and Connective Tissue Diseases::Skin Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Dermatitis, Atopic
ORGANISMS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus
ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::enfermedades de la piel y tejido conjuntivo::enfermedades de la piel::dermatitis atópica
ORGANISMOS::Bacteria::Bacteria::Firmicutes::Bacillales::Staphylococcaceae::Staphylococcus::Bacteria::Bacteria::Staphylococcus aureus
ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T
Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
Dermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la piel
Dermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pell
Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.
2025-10-24T10:59:16Z
2025-10-24T10:59:16Z
2025-10-24T10:59:16Z
2022-09-13T07:23:21Z
2022-09-13T07:23:21Z
2022-06-30
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://hdl.handle.net/11351/8173
Allergy;
https://doi.org/10.1111/all.15424
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
Wiley
Scientia